Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

被引：236

作者：

Gray, Ryan S. ^{[1
]}

Roszko, Isabelle ^{[1
]}

Solnica-Krezel, Lilianna ^{[1
]}

机构：

[1] Washington Univ, Sch Med St Louis, Dept Dev Biol, St Louis, MO 63110 USA

来源：

DEVELOPMENTAL CELL | 2011年 / 21卷 / 01期

关键词：

CONVERGENT EXTENSION MOVEMENTS; NEURAL-TUBE DEFECTS; INTRAFLAGELLAR TRANSPORT PROTEINS; RIGHT AXIS DETERMINATION; BARDET-BIEDL-SYNDROME; TISSUE POLARITY; ZEBRAFISH GASTRULATION; INNER-EAR; ASYMMETRIC LOCALIZATION; SIGNALING CONTROLS;

D O I：

10.1016/j.devcel.2011.06.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

引用

页码：120 / 133

页数：14

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