Regulation of Ferroptosis by Non-Coding RNAs in Head and Neck Cancers

被引：11
作者：
Hsieh, Pei-Ling [1 ]
Chao, Shih-Chi [2 ,3 ]
Chu, Pei-Ming [1 ]
Yu, Cheng-Chia [2 ,4 ,5 ]
机构：
[1] China Med Univ, Sch Med, Dept Anat, Taichung 404333, Taiwan
[2] Chung Shan Med Univ, Inst Oral Sci, Taichung 40201, Taiwan
[3] Lotung Poh Ai Hosp, Lo Hsu Med Fdn, Dept Med Res & Educ, Yilan 265, Taiwan
[4] Chung Shan Med Univ, Sch Dent, Taichung 40201, Taiwan
[5] Chung Shan Med Univ Hosp, Dept Dent, Taichung 40201, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 06期
关键词：
ferroptosis; non-coding RNAs; head and neck cancers; SQUAMOUS-CELL CARCINOMA; NASOPHARYNGEAL CARCINOMA; STEM-CELLS; CISPLATIN RESISTANCE; MOLECULAR-MECHANISMS; TRANSFERRIN RECEPTOR; TUMOR-GROWTH; ORAL-CANCER; IRON; PROLIFERATION;
D O I：
10.3390/ijms23063142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ferroptosis is a newly identified mode of programmed cell death characterized by iron-associated accumulation of lipid peroxides. Emerging research on ferroptosis has suggested its implication in tumorigenesis and stemness of cancer. On the other hand, non-coding RNAs have been shown to play a pivotal role in the modulation of various genes that affect the progression of cancer cells and ferroptosis. In this review, we summarize recent advances in the theoretical modeling of ferroptosis and its relationship between non-coding RNAs and head and neck cancers. Aside from the significance of ferroptosis-related non-coding RNAs in prognostic relevance, we also review how these non-coding RNAs participate in the regulation of iron, lipid metabolism, and reactive oxygen species accumulation. We aim to provide a thorough grounding in the function of ferroptosis-related non-coding RNAs based on current knowledge in an effort to develop effective therapeutic strategies for head and neck cancers.
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页数：15
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