MR-optical imaging of cardiovascular molecular targets

被引：20
作者：
Nahrendorf, Matthias [1 ,2 ]
Sosnovik, David E. [3 ]
Weissleder, Ralph [1 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA
来源：
BASIC RESEARCH IN CARDIOLOGY | 2008年 / 103卷 / 02期
关键词：
atherosclerosis; molecular imaging; fluorescence; MRI;
D O I：
10.1007/s00395-008-0707-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Our understanding of the intricate inflammation biology underlying atherosclerosis is rapidly progressing. Molecular imaging strategies, harnessing this body of knowledge, have been developed to visualize some key cellular and molecular events in plaque evolution and vulnerability. Here, we discuss recent advances in magnetic resonance and fluorescence imaging of key biomarkers including adhesion molecules, inflammatory cells, and enzyme activity. We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches.
引用
收藏
页码：87 / 94
页数：8
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