The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

被引：159

作者：

Motomura, Yasutaka ^{[1
,2
]}

Kitamura, Hiroshi ^{[3
]}

Hijikata, Atsushi ^{[3
]}

Matsunaga, Yuko ^{[4
]}

Matsumoto, Koichiro ^{[4
]}

Inoue, Hiromasa ^{[4
]}

Atarashi, Koji ^{[5
]}

Hori, Shohei ^{[6
]}

Watarai, Hiroshi ^{[7
]}

Zhu, Jinfang ^{[8
]}

Taniguchi, Masaru ^{[7
]}

Kubo, Masato ^{[1
,2
]}

机构：

[1] RIKEN Yokohama Inst, Res Ctr Allergy & Immunol, Lab Signal Network, Yokohama, Kanagawa, Japan

[2] Tokyo Univ Sci, Res Inst Biol Sci, Div Mol Pathol, Chiba, Japan

[3] RIKEN Yokohama Inst, Res Ctr Allergy & Immunol, Lab Immunogenom, Yokohama, Kanagawa, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Res Inst Dis Chest, Fukuoka 812, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo, Japan

[6] RIKEN Yokohama Inst, Res Ctr Allergy & Immunol, Lab Immune Homeostasis, Yokohama, Kanagawa, Japan

[7] RIKEN Yokohama Inst, Res Ctr Allergy & Immunol, Lab Immune Regulat, Yokohama, Kanagawa, Japan

[8] NIAID, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 05期

关键词：

GENE-EXPRESSION; IFN-GAMMA; HUMAN TH1; TGF-BETA; RESPONSES; CYTOKINE; LINEAGE; GATA-3; MICE; HYPERRESPONSIVENESS;

D O I：

10.1038/ni.2020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (T(H)2) cells but also by T(H)1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic T(H)1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3(-/-); called 'E4bp4(-/-)' here) T(H)1 cells, regulatory T cells (T-reg cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional T(H)1 cells. E4bp4(-/-) T(H)2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T-reg cells and NKT cells.

引用

页码：450 / U111

页数：11

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