Design of molecular imprinted polymers compatible with aqueous environment

被引：74

作者：

Piletska, Elena V. ^{[1
]}

Guerreiro, Antonio R. ^{[1
]}

Romero-Guerra, Maria ^{[1
]}

Chianella, Iva ^{[1
]}

Turner, Anthony P. F. ^{[1
]}

Piletsky, Sergey A. ^{[1
]}

机构：

[1] Cranfield Univ, Bedford MK45 4DT, England

来源：

ANALYTICA CHIMICA ACTA | 2008年 / 607卷 / 01期

关键词：

potentiometric titration; cocaine; deoxyephedrine; methadone; molecular imprinting;

D O I：

10.1016/j.aca.2007.11.019

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The main problem of poor water compatibility of molecularly imprinted polymers (MIPs) was addressed in examples describing design of synthetic receptors with high affinity for drugs of abuse. An extensive potentiometric titration of 10 popular functional monomers and corresponding imprinted and Blank polymers was conducted in order to evaluate the subtleties of functional groups ionisation under aqueous conditions. It was found that polymers prepared using 2-trifluoromethacrylic acid (TFMAA) in combination with toluene as porogen possess superior properties which make them suitable for effective template recognition in water. The potential impact of phase separation during polymerisation on formation of high quality imprints has been discussed. Three drugs of abuse such as cocaine, deoxyephedrine and methadone were used as template models in polymer preparation for the practical validation of obtained results. The polymer testing showed that synthesized molecularly imprinted polymers have high affinity and selectivity for corresponding templates in aqueous environment, with imprinting factors of 2.6 for cocaine and 1.4 for methadone and deoxyephedrine. Corresponding Blank polymers were unable to differentiate between analytes, suggesting that imprinting phenomenon was responsible for the recognition properties. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：54 / 60

页数：7

共 22 条

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