Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

被引：178

作者：

He, Mei ^{[1
]}

Kubo, Hiroshi ^{[1
]}

Morimoto, Konosuke ^{[2
]}

Fujino, Naoya ^{[1
]}

Suzuki, Takaya ^{[3
]}

Takahasi, Toru ^{[4
]}

Yamada, Mitsuhiro ^{[5
]}

Yamaya, Mutsuo ^{[1
]}

Maekawa, Tomoyuki ^{[2
]}

Yamamoto, Yasuhiko ^{[6
]}

Yamamoto, Hiroshi ^{[6
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Adv Prevent Med Infect Dis, Sendai, Miyagi 9808575, Japan

[2] Nagasaki Univ, Inst Trop Med, Dept Clin Med, Nagasaki 8528523, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Thorac Surg, Sendai, Miyagi 9808575, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Anesthesiol, Sendai, Miyagi 9808575, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Infect Control & Lab Diagnost, Sendai, Miyagi 9808575, Japan

[6] Kanazawa Univ, Grad Sch Med Sci, Dept Biochem & Mol Vasc Biol, Kanazawa, Ishikawa 9208640, Japan

来源：

EMBO REPORTS | 2011年 / 12卷 / 04期

基金：

日本学术振兴会;

关键词：

macrophage; phagocytosis; phosphatidylserine; apoptosis; RAGE; CORPSE CLEARANCE; LUNG INJURY; RAGE; NEUTROPHILS; MICE; PHAGOCYTOSIS; INFLAMMATION; RECOGNITION; ENGULFMENT; IDENTIFICATION;

D O I：

10.1038/embor.2011.28

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an 'eat-me' signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage(-/-)) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage(-/-) mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.

引用

页码：358 / 364

页数：7

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