Use-Dependent Hemispheric Balance

被引:95
作者
Avanzino, Laura [1 ,2 ,3 ]
Bassolino, Michela [4 ,5 ]
Pozzo, Thierry [4 ,6 ]
Bove, Marco [1 ,2 ,7 ]
机构
[1] Univ Genoa, Dept Expt Med, Sect Human Physiol, I-16126 Genoa, Italy
[2] Univ Genoa, Ctr Polifunz Sci Motorie, I-16126 Genoa, Italy
[3] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16126 Genoa, Italy
[4] Univ Genoa, Ist Italiano Tecnol, I-16126 Genoa, Italy
[5] Univ Genoa, Dept Commun Comp & Syst Sci, I-16126 Genoa, Italy
[6] Inst Univ France, INSERM, Unite Motricite Plasticite 887, F-21065 Dijon, France
[7] Ist Nazl Neurosci, I-10125 Turin, Italy
关键词
TRANSCRANIAL MAGNETIC STIMULATION; IPSILATERAL MOTOR CORTEX; INTERHEMISPHERIC INTERACTIONS; REPETITIVE TMS; AREAS; 3A; HAND; EXCITABILITY; INHIBITION; PLASTICITY; IMMOBILIZATION;
D O I
10.1523/JNEUROSCI.4893-10.2011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the human brain, homologous regions of the primary motor cortices (M1s) are connected through transcallosal fibers. Interhemispheric communication between the two M1s plays a major role in the control of unimanual hand movements, and the strength of this connection seems to be dependent on arm activity. For instance, a lesion in the M1 can induce an increase in the excitability of the intact M1 and an abnormal high inhibitory influence onto the damaged M1. This can be attributable to either the disuse of the affected limb or the overuse of the unaffected one. Here, to directly investigate cortical modifications induced by an abnormal asymmetric use of the two limbs, we studied both the excitability of the two M1s and transcallosal interaction between them in healthy subjects whose right hand was immobilized for 10 h. The left "not-immobilized" arm was completely free to move in one group of participants (G1) and limited in the other one (G2). We found that the non-use reduced the excitability of the left M1 and decreased the inhibitory influence onto the right hemisphere in the two groups. However, an increase in the excitability of right M1 and a deeper inhibitory interaction onto the left hemisphere were evident only in G1. Thus, modifications in the right M1 were not directly produced by the non-use but would depend on the overuse of the "not-immobilized" arm. Our findings suggest that the balance between the two M1s is strongly use dependent.
引用
收藏
页码:3423 / 3428
页数:6
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