Cardiovascular risk estimated in individuals with multiple sclerosis: A case-control study

被引:10
作者
Albuquerque, Larissa da Silva [1 ]
Damasceno, Nagila Raquel Teixeira [2 ]
Maia, Fernanda Nunes [1 ]
de Carvalho, Beatriz Melo [3 ]
Maia, Carla Soraya Costa [1 ]
D'Almeida, Jose Artur Costa [4 ]
de Melo, Maria Luisa Pereira [1 ,2 ,4 ]
机构
[1] Ceara State Univ UECE, Postgrad Program Nutr & Hlth, Dr Silas Munguba Ave 1700,Campus Itaperi, BR-60714903 Fortaleza, CE, Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Postgrad Program Appl Human Nutr PRONUT, Sao Paulo, Brazil
[3] Ceara State Univ UECE, Grad Course Nutr, Fortaleza, Ceara, Brazil
[4] Fortaleza Gen Hosp HGF SUS, Neurol Dept, Multiple Sclerosis Interdisciplinary Ctr, Fortaleza, Ceara, Brazil
关键词
Multiple sclerosis; Cardiovascular disease; Cardiometabolic risk; Dyslipidemia; Nutritional assessment; DENSITY-LIPOPROTEIN CHOLESTEROL; ATHEROGENIC INDEX; A-I; PLASMA; RATIO; PREVALENCE; DISABILITY; RESISTANCE; INDICATOR; EXERCISE;
D O I
10.1016/j.msard.2021.103133
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Patients with multiple sclerosis (MS) had a 1.5-fold increase in cardiovascular diseases (CVD) mortality, compared with those without MS. Therefore, the aim of this study was to assess the CVD risk in MS patients by multiple cardiometabolic indexes and to investigate associated factors. Methods: The MS group included 57 patients matched for age and sex to 57 healthy controls. They were evaluated for physical activity, smoking, anthropometric indices, blood pressure, and plasma biomarkers. Framingham risk score (FRS) and multiple cardiovascular risk indexes were calculated. Clinical course of disease, age at onset, disease duration, disease-modifying therapy, relapse rate, EDSS, physical and functional impairment were investigated. Results: The mean age was 34.6 years old. The majority (89.5%) in the MS group had a RRMS clinical course and a mild level of disability (EDSS=1.0). WC (p = 0.022) and FM% (p = 0.007) were different between the MS and control groups. The FRS was higher in the MS group (10% versus 0%) and this was related with high prevalence of dyslipidemia (43.8% versus 36.8%). The atherogenic index of plasma (AIP) (0.013) and Castelli risk indexes I (CRI-I) (p = 0.017) and II (CRI-II) (p = 0.008) and non-HDL-C (p = 0.044) were higher in the MS group. Conclusion: MS patients, with controlled disease course, have a higher cardiovascular risk than comparable healthy individuals. We emphasize that the use of FRS, and the monitoring of CRI-I and II, as well as AIP, are important lipid markers to manage CVD risk in individuals with MS.
引用
收藏
页数:7
相关论文
共 53 条
[1]  
[Anonymous], 1991, ANTHROPOMETRIC STAND
[2]  
[Anonymous], Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat
[3]  
Arnett DK, 2019, CIRCULATION, V140, pE596, DOI [10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.010, 10.1016/j.jacc.2019.03.009, 10.1161/CIR.0000000000000677]
[4]   Sarcopenic obesity in ageing: cardiovascular outcomes and mortality [J].
Atkins, Janice L. ;
Wannamathee, S. Goya .
BRITISH JOURNAL OF NUTRITION, 2020, 124 (10) :1102-1113
[5]  
Blumenfeld Kan S, 2019, MULT SCLER J-EXP TRA, V5, P1, DOI DOI 10.1177/2055217319882720
[6]   The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population [J].
Cai, Gaojun ;
Shi, Ganwei ;
Xue, Sheliang ;
Lu, Wei .
MEDICINE, 2017, 96 (37)
[7]  
Cardiology Brazilian Society, 2017, ARQ BRAS CARDIOL, V109, P1, DOI [10.5935/abc.20170121, DOI 10.5935/ABC.20170121]
[8]   Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment [J].
Carr, Stuart S. ;
Hooper, Amanda J. ;
Sullivan, David R. ;
Burnett, John R. .
PATHOLOGY, 2019, 51 (02) :148-154
[9]   SUMMARY ESTIMATES OF CHOLESTEROL USED TO PREDICT CORONARY HEART-DISEASE [J].
CASTELLI, WP ;
ABBOTT, RD ;
MCNAMARA, PM .
CIRCULATION, 1983, 67 (04) :730-734
[10]   General cardiovascular risk profile for use in primary care - The Framingham Heart Study [J].
D'Agostino, Ralph B. ;
Vasan, Ramachandran S. ;
Pencina, Michael J. ;
Wolf, Philip A. ;
Cobain, Mark ;
Massaro, Joseph M. ;
Kannel, William B. .
CIRCULATION, 2008, 117 (06) :743-753