Fucoidans in Nanomedicine

被引：91

作者：

Chollet, Lucas ^{[1
,2
,3
]}

Saboural, Pierre ^{[1
,2
]}

Chauvierre, Cedric ^{[1
,2
]}

Villemin, Jean-Noel ^{[3
]}

Letourneur, Didier ^{[1
,2
]}

Chaubet, Frederic ^{[1
,2
]}

机构：

[1] Univ Paris Diderot, Bichat Hosp 10, INSERM, LVTS,U1148, F-75877 Paris, France

[2] Univ Paris 13, Sorbonne Paris Cite, Galilee Inst, F-93430 Villetaneuse, France

[3] Algues & Mer, F-29242 Kernigou, Ouessant, France

来源：

MARINE DRUGS | 2016年 / 14卷 / 08期

关键词：

fucoidans; nanomedicine; sulfated polysaccharides; nanosystems; drug delivery; imaging agent; tissue regeneration; MOLECULAR-WEIGHT FUCOIDAN; FUNCTIONALIZED POLYSACCHARIDE MICROPARTICLES; INDUCED TUBE FORMATION; HERPES-SIMPLEX-VIRUS; COMBINED PHASE-I; SULFATED POLYSACCHARIDES; MARINE POLYSACCHARIDES; EXTRACELLULAR-MATRIX; ASCOPHYLLUM-NODOSUM; GAMMA-IRRADIATION;

D O I：

10.3390/md14080145

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fucoidans are widespread cost-effective sulfated marine polysaccharides which have raised interest in the scientific community over last decades for their wide spectrum of bioactivities. Unsurprisingly, nanomedicine has grasped these compounds to develop innovative therapeutic and diagnostic nanosystems. The applications of fucoidans in nanomedicine as imaging agents, drug carriers or for their intrinsic properties are reviewed here after a short presentation of the main structural data and biological properties of fucoidans. The origin and the physicochemical specifications of fucoidans are summarized in order to discuss the strategy of fucoidan-containing nanosystems in Human health. Currently, there is a need for reproducible, well characterized fucoidan fractions to ensure significant progress.

引用

页数：24

共 203 条

[51] Effects of polysaccharide fucoidin on cerebrospinal fluid interleukin-1 and tumor necrosis factor alpha in pneumococcal meningitis in the rabbit [J].