Fucoidans in Nanomedicine

被引：91
作者：
Chollet, Lucas [1 ,2 ,3 ]
Saboural, Pierre [1 ,2 ]
Chauvierre, Cedric [1 ,2 ]
Villemin, Jean-Noel [3 ]
Letourneur, Didier [1 ,2 ]
Chaubet, Frederic [1 ,2 ]
机构：
[1] Univ Paris Diderot, Bichat Hosp 10, INSERM, LVTS,U1148, F-75877 Paris, France
[2] Univ Paris 13, Sorbonne Paris Cite, Galilee Inst, F-93430 Villetaneuse, France
[3] Algues & Mer, F-29242 Kernigou, Ouessant, France
来源：
MARINE DRUGS | 2016年 / 14卷 / 08期
关键词：
fucoidans; nanomedicine; sulfated polysaccharides; nanosystems; drug delivery; imaging agent; tissue regeneration; MOLECULAR-WEIGHT FUCOIDAN; FUNCTIONALIZED POLYSACCHARIDE MICROPARTICLES; INDUCED TUBE FORMATION; HERPES-SIMPLEX-VIRUS; COMBINED PHASE-I; SULFATED POLYSACCHARIDES; MARINE POLYSACCHARIDES; EXTRACELLULAR-MATRIX; ASCOPHYLLUM-NODOSUM; GAMMA-IRRADIATION;
D O I：
10.3390/md14080145
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fucoidans are widespread cost-effective sulfated marine polysaccharides which have raised interest in the scientific community over last decades for their wide spectrum of bioactivities. Unsurprisingly, nanomedicine has grasped these compounds to develop innovative therapeutic and diagnostic nanosystems. The applications of fucoidans in nanomedicine as imaging agents, drug carriers or for their intrinsic properties are reviewed here after a short presentation of the main structural data and biological properties of fucoidans. The origin and the physicochemical specifications of fucoidans are summarized in order to discuss the strategy of fucoidan-containing nanosystems in Human health. Currently, there is a need for reproducible, well characterized fucoidan fractions to ensure significant progress.
引用
收藏
页数：24
相关论文
共 203 条
[1]   Anti-metastatic effects of the sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum on B16 melanoma [J].
Abu, Ryogo ;
Jiang, Zedong ;
Ueno, Mikinori ;
Isaka, Shogo ;
Nakazono, Satoru ;
Okimura, Takasi ;
Cho, Kichul ;
Yamaguchi, Kenichi ;
Kim, Daekyung ;
Oda, Tatsuya .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (04) :727-732
[2]   Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation [J].
Ale, Marcel Tutor ;
Meyer, Anne S. .
RSC ADVANCES, 2013, 3 (22) :8131-8141
[3]   Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds [J].
Ale, Marcel Tutor ;
Mikkelsen, Jorn D. ;
Meyer, Anne S. .
MARINE DRUGS, 2011, 9 (10) :2106-2130
[4]   Sulfated polysaccharides from the egg jelly layer are species-specific inducers of acrosomal reaction in sperms of sea urchins [J].
Alves, AP ;
Mulloy, B ;
Diniz, JA ;
Mourao, PAS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (11) :6965-6971
[5]   Synthesis and Characterization of Fucan-Coated Cobalt Ferrite Nanoparticles [J].
Andrade, P. L. ;
Silva, V. A. J. ;
Silva, M. P. C. ;
Albino Aguiar, J. .
JOURNAL OF SUPERCONDUCTIVITY AND NOVEL MAGNETISM, 2013, 26 (07) :2511-2514
[6]   Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential [J].
Atashrazm, Farzaneh ;
Lowenthal, Ray M. ;
Woods, Gregory M. ;
Holloway, Adele F. ;
Dickinson, Joanne L. .
MARINE DRUGS, 2015, 13 (04) :2327-2346
[7]   Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model [J].
Azuma, Kazuo ;
Ishihara, Toshitsugu ;
Nakamoto, Hiroyuki ;
Amaha, Takao ;
Osaki, Tomohiro ;
Tsuka, Takeshi ;
Imagawa, Tomohiro ;
Minami, Saburo ;
Takashima, Osamu ;
Ifuku, Shinsuke ;
Morimoto, Minoru ;
Saimoto, Hiroyuki ;
Kawamoto, Hitoshi ;
Okamoto, Yoshiharu .
MARINE DRUGS, 2012, 10 (10) :2337-2348
[8]   SULFATED POLYSACCHARIDES ARE POTENT AND SELECTIVE INHIBITORS OF VARIOUS ENVELOPED VIRUSES, INCLUDING HERPES-SIMPLEX VIRUS, CYTOMEGALO-VIRUS, VESICULAR STOMATITIS-VIRUS, AND HUMAN IMMUNODEFICIENCY VIRUS [J].
BABA, M ;
SNOECK, R ;
PAUWELS, R ;
DECLERCQ, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (11) :1742-1745
[9]   Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets [J].
Bachelet, Laure ;
Bertholon, Isabelle ;
Lavigne, Damien ;
Vassy, Roger ;
Jandrot-Perrus, Martine ;
Chaubet, Frederic ;
Letourneur, Didier .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (02) :141-146
[10]   Strong and specific interaction of ultra small superparamagnetic iron oxide nanoparticles and human activated platelets mediated by fucoidan coating [J].
Bachelet-Violette, Laure ;
Silva, Amanda K. A. ;
Maire, Murielle ;
Michel, Aude ;
Brinza, Ovidiu ;
Ou, Phalla ;
Ollivier, Veronique ;
Nicoletti, Antonino ;
Wilhelm, Claire ;
Letourneur, Didier ;
Menager, Christine ;
Chaubet, Frederic .
RSC ADVANCES, 2014, 4 (10) :4864-4871
12345678910