Aging and Lung Disease

被引：298

作者：

Cho, Soo Jung ^{[1
]}

Stout-Delgado, Heather W. ^{[1
]}

机构：

[1] Weill Cornell Med, Dept Med, Div Pulm & Crit Care Med, New York, NY 10065 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 | 2020年 / 82卷

基金：

美国国家卫生研究院;

关键词：

lung aging; inflammation; chronic obstructive pulmonary disease; COPD; interstitial pulmonary fibrosis; IPF; acute respiratory distress syndrome; ARDS; pneumonia; OBSTRUCTIVE PULMONARY-DISEASE; INNATE IMMUNE-RESPONSES; AGE-RELATED ALTERATIONS; SURFACTANT PROTEIN-C; DENDRITIC CELLS; ANTIMICROBIAL ACTIVITY; VENTILATORY RESPONSES; ALVEOLAR MACROPHAGES; EMPHYSEMATOUS LUNGS; CELLULAR SENESCENCE;

D O I：

10.1146/annurev-physiol-021119-034610

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

People worldwide are living longer, and it is estimated that by 2050, the proportion of the world's population over 60 years of age will nearly double. Natural lung aging is associated with molecular and physiological changes that cause alterations in lung function, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to acute and chronic lung diseases. As the aging population rapidly grows, it is essential to examine how alterations in cellular function and cell-to-cell interactions of pulmonary resident cells and systemic immune cells contribute to a higher risk of increased susceptibility to infection and development of chronic diseases, such as chronic obstructive pulmonary disease and interstitial pulmonary fibrosis. This review provides an overview of physiological, structural, and cellular changes in the aging lung and immune system that facilitate the development and progression of disease.

引用

页码：433 / 459

页数：27

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