Emerging insights in the management of hemoglobin E beta thalassemia

被引：8

作者：

Olivieri, Nancy F. ^{[1
]}

Thayalsuthan, Vivekanandan ^{[1
]}

O'Donnell, Angela ^{[2
]}

Premawardhena, Anuja ^{[3
]}

Rigobon, Christopher ^{[1
]}

Muraca, Giulia ^{[1
]}

Fisher, Christopher ^{[4
]}

Weatherall, David J. ^{[2
]}

机构：

[1] Univ Toronto, Toronto Gen Hosp, Hemoglobinopathy Res Program, Toronto, ON M5G 2C4, Canada

[2] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DU, England

[3] Univ Kelaniya, Fac Med, Colombo, Sri Lanka

[4] John Radcliffe Hosp, MRC, Mol Hematol Unit, Oxford OX3 9DU, England

来源：

COOLEY'S ANEMIA: NINTH SYMPOSIUM | 2010年 / 1202卷

关键词：

hemoglobin; hemoglobin E beta thalassemia; beta thalassemia; SRI-LANKA; DISORDERS; GENE;

D O I：

10.1111/j.1749-6632.2010.05579.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Globally, hemoglobin (lib) E beta thalassemia accounts for approximately half the severe forms of eta thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of HI) E beta thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition.

引用

页码：155 / 157

页数：3

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