Vascular endothelial growth factor in tumor tissue and blood serum from patients with breast cancer

被引:4
作者
Gershtein, ES [1 ]
Shcherbakov, AM [1 ]
Alieva, SK [1 ]
Anurova, OA [1 ]
Laktionov, KP [1 ]
Kushlinskii, NE [1 ]
机构
[1] Russian Acad Med Sci, NN Blokhin Russian Oncol Ctr, Lab Clin Biochem, Moscow, Russia
关键词
vascular endothelial growth factor; breast cancer; angiogenesis;
D O I
10.1023/A:1023414400387
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Enzyme immunoassay showed that the content of free vascular endothelial growth factor increases in tumor cytosols and blood serum from patients with breast cancer. A positive correlation was found between the contents of vascular endothelial growth factor in tumor cytosols and blood serum. After removal of the tumor the content of vascular endothelial growth factor decreased only in 49% patients. It should be emphasized that changes in these parameters did not depend on their initial values.
引用
收藏
页码:85 / 88
页数:4
相关论文
共 15 条
[1]  
Adams J, 2000, CANCER RES, V60, P2898
[2]  
Borgström P, 1999, ANTICANCER RES, V19, P4203
[3]   Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer - A more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor [J].
Callagy, G ;
Dimitriadis, E ;
Harmey, J ;
Bouchier-Hayes, D ;
Leader, M ;
Kay, E .
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2000, 8 (02) :104-109
[4]   Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients [J].
Eppenberger, U ;
Kueng, W ;
Schlaeppi, JM ;
Roesel, JL ;
Benz, C ;
Mueller, H ;
Matter, A ;
Zuber, M ;
Luescher, K ;
Litschgi, M ;
Schmitt, M ;
Foekens, JA ;
Eppenberger-Castori, S .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (09) :3129-3136
[5]   THE ROLE OF VASCULAR ENDOTHELIAL GROWTH-FACTOR IN PATHOLOGICAL ANGIOGENESIS [J].
FERRARA, N .
BREAST CANCER RESEARCH AND TREATMENT, 1995, 36 (02) :127-137
[6]  
Foekens JA, 2001, CANCER RES, V61, P5407
[7]  
Folkman J., 2001, HARRISONS PRINCIPLES, V15th ed., P517
[8]  
Gasparini G, 2000, Oncologist, V5 Suppl 1, P37
[9]  
Gershtein E S, 2000, Klin Lab Diagn, P16
[10]  
Harris AL, 1998, RECENT RES CANCER, V152, P341