The Mechanisms of Sevoflurane- Induced Neuroinflammation

被引：35
作者：
Huang, Xiangfei [1 ,2 ]
Ying, Jun [1 ,2 ]
Yang, Danying [1 ,2 ]
Fang, Pu [3 ]
Wang, Xifeng [4 ]
Zhou, Bin [1 ,2 ]
Zhang, Lieliang [1 ,2 ]
Fang, Yang [1 ,2 ]
Yu, Wen [1 ,2 ]
Liu, Xing [1 ,2 ]
Zhen, Qingcui [1 ,2 ]
Hua, Fuzhou [1 ,2 ]
机构：
[1] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China
[2] Key Lab Anesthesiol Jiangxi Prov, Nanchang, Jiangxi, Peoples R China
[3] Nanchang Univ, Dept Neurol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
[4] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2021年 / 13卷
基金：
中国国家自然科学基金;
关键词：
sevoflurane; neuroinflammation; microglia; blood-brain barrier; gut microbiota; cholinergic neurotransmission; BLOOD-BRAIN-BARRIER; KAPPA-B PATHWAY; ANESTHETIC SEVOFLURANE; MICROGLIAL ACTIVATION; ACETYLCHOLINE-RELEASE; COGNITIVE DYSFUNCTION; VOLATILE ANESTHETICS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; CHOLINERGIC SYSTEM;
D O I：
10.3389/fnagi.2021.717745
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood-brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment.
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页数：10
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