Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease

被引：20

作者：

Arora, Siddharth ^{[1
]}

Visanji, Naomi P. ^{[2
,3
,4
]}

Mestre, Tiago A. ^{[5
]}

Tsanas, Athanasios ^{[6
]}

AlDakheel, Amaal ^{[2
,3
,4
]}

Connolly, Barbara S. ^{[7
]}

Gasca-Salas, Carmen ^{[2
,3
,4
]}

Kern, Drew S. ^{[8
]}

Jain, Jennifer ^{[2
,3
,4
]}

Slow, Elizabeth J. ^{[2
,3
,4
]}

Faust-Socher, Achinoam ^{[2
,3
,4
]}

Lang, Anthony E. ^{[2
,3
,4
]}

Little, Max A. ^{[9
,10
]}

Marras, Connie ^{[2
,3
,4
]}

机构：

[1] Univ Oxford, Somerville Coll, Oxford, England

[2] Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[3] Morton & Gloria Shulman Movement Disorders Ctr, Toronto, ON, Canada

[4] Toronto Western Hosp, Toronto, ON, Canada

[5] Univ Ottawa, Brain & Mind Inst, Parkinsons Dis & Movement Disorders Ctr, Ottawa Hosp Res Inst,Div Neurol,Dept Med, Ottawa, ON, Canada

[6] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

[7] McMaster Univ, Hamilton Hlth Sci, Div Neurol, Dept Med, Hamilton, ON, Canada

[8] Univ Colorado, Dept Neurol, Movement Disorders Ctr, Anschutz Med Campus, Aurora, CO USA

[9] Aston Univ, Engn & Appl Sci, Birmingham, W Midlands, England

[10] MIT, Media Lab, Cambridge, MA 02139 USA

来源：

JOURNAL OF PARKINSONS DISEASE | 2018年 / 8卷 / 04期

关键词：

LRRK2; mutation; Parkinson's disease; biomarker; voice; LARGE-SAMPLE; SPEECH; VARIABILITY; ALGORITHMS; PHENOTYPE; RELEVANCE; FREQUENCY; SELECTION; CRITERIA;

D O I：

10.3233/JPD-181389

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-as sociated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

引用

页码：503 / 510

页数：8

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[1] A survey of cross-validation procedures for model selection [J].