Renin inhibition: What are the therapeutic opportunities?

被引：148
作者：
Fisher, NDL
Hollenberg, NK
机构：
[1] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2005年 / 16卷 / 03期
关键词：
D O I：
10.1681/ASN.2004100874
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has become a crucial element in cardiovascular and renal medicine. This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption.
引用
收藏
页码：592 / 599
页数：8
相关论文
共 51 条
[1]   Dual blockade with candesartan cilexetil and lisinopril in hypertensive patients with diabetes mellitus:: rationale and design [J].
Andersen, NH ;
Knudsen, ST ;
Poulsen, PL ;
Poulsen, SH ;
Helleberg, K ;
Eiskjær, H ;
Hansen, KW ;
Bek, T ;
Mogensen, CE .
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2003, 4 (02) :96-99
[2]  
BEZENCON O, 2004, 228 NAT M PHIL PA AU
[3]   CONTROL ANALYSIS APPLIED TO SINGLE ENZYMES - CAN AN ISOLATED ENZYME HAVE A UNIQUE RATE-LIMITING STEP [J].
BROWN, GC ;
COOPER, CE .
BIOCHEMICAL JOURNAL, 1993, 294 :87-94
[4]   SPECIFIC-INHIBITION OF RENIN BY AN ANGIOTENSINOGEN ANALOG - STUDIES IN SODIUM DEPLETION AND RENIN-DEPENDENT HYPERTENSION [J].
BURTON, J ;
CODY, RJ ;
HERD, JA ;
HABER, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (09) :5476-5479
[5]   RENAL AND ENDOCRINE RESPONSES TO A RENIN INHIBITOR, ENALKIREN, IN NORMAL HUMANS [J].
CORDERO, P ;
FISHER, ND ;
MOORE, TJ ;
GLEASON, R ;
WILLIAMS, GH ;
HOLLENBERG, NK .
HYPERTENSION, 1991, 17 (04) :510-516
[6]   RENIN, PRORENIN, AND IMMUNOREACTIVE RENIN IN VITREOUS FLUID FROM EYES WITH AND WITHOUT DIABETIC-RETINOPATHY [J].
DANSER, AHJ ;
VANDENDORPEL, MA ;
DEINUM, J ;
DERKX, FHM ;
FRANKEN, AAM ;
PEPERKAMP, E ;
DEJONG, PTVM ;
SCHALEKAMP, MADH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (01) :160-167
[7]   IDENTIFICATION AND QUANTIFICATION OF RENIN AND PRORENIN IN THE BOVINE EYE [J].
DEINUM, J ;
DERKX, FHM ;
DANSER, AHJ ;
SCHALEKAMP, MADH .
ENDOCRINOLOGY, 1990, 126 (03) :1673-1682
[8]  
DERKX FHM, 1987, THESIS ERASMUS U ROT
[9]   ANTIBODIES AS SPECIFIC RENIN INHIBITORS - STUDIES WITH POLYCLONAL AND MONOCLONAL-ANTIBODIES AND FAB FRAGMENTS [J].
DZAU, VJ ;
DEVINE, D ;
MUDGETTHUNTER, M ;
KOPELMAN, RI ;
BARGER, AC ;
HABER, E .
CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1983, 5 (7-8) :1207-1220
[10]   EFFECTS OF BLOCKING THE ANGIOTENSIN-II RECEPTOR, CONVERTING-ENZYME, AND RENIN-ACTIVITY ON THE RENAL HEMODYNAMICS OF NORMOTENSIVE GUINEA-PIGS [J].
ELAMRANI, AIK ;
MENARD, J ;
GONZALES, MF ;
MICHEL, JB .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 (02) :231-239
123456