Inflammation and metabolic dysfunction are hallmarks of the progression of non-alcoholic fatty liver disease (NAFLD), which is the fastest-growing liver disease worldwide. Emerging evidence indicates that innate immune mechanisms are essential drivers of fibrosis development in chronic inflammatory liver diseases, including NAFLD. In this study, 142 NAFLD patients were genotyped for three IFNL4 single-nucleotide variants in order to investigate the genetic relationship between IFNL4 and fibrosis in NAFLD patients. We observed an overrepresentation of the non-functional IFNL4 allele in patients with significant fibrosis (>F2). Next, we investigated the potential protective role of interferon (IFN) in relation to the development of liver fibrosis in an animal model of non-alcoholic steatohepatitis (NASH). In contradiction to our hypothesis, the results showed an increase in fibrosis in IFN treated animals. Our study clearly indicates that IFN is able to affect the development of liver fibrosis, although our clinical and experimental data are conflicting.
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Univ Paris Est Creteil Val de Marne, Grp Hosp Henri Mondor, F-94010 Creteil, FranceUniv Paris Est Creteil Val de Marne, Grp Hosp Henri Mondor, F-94010 Creteil, France
Calderaro, Julien
Zafrani, Elie Serge
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Univ Paris Est Creteil Val de Marne, Grp Hosp Henri Mondor, F-94010 Creteil, FranceUniv Paris Est Creteil Val de Marne, Grp Hosp Henri Mondor, F-94010 Creteil, France
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Canberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
Australian Natl Univ, Med Sch, Canberra, ACT, AustraliaCanberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
Farrell, Geoffrey C.
Wardell, Rebecca
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Canberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
Australian Natl Univ, Med Sch, Canberra, ACT, AustraliaCanberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
Wardell, Rebecca
Teoh, Narci
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Canberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
Australian Natl Univ, Med Sch, Canberra, ACT, AustraliaCanberra Hosp, Gastroenteorl & Hepatol Unit, Canberra, ACT, Australia
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Gazi Univ, Dept Gen Surg, Fac Med, Ankara, Turkey
Mustafa Kemal Mah 2137 Sok 8-14, TR-06520 Ankara, TurkeyGazi Univ, Dept Gen Surg, Fac Med, Ankara, Turkey
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Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Alba, LM
Lindor, K
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Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA