Atherogenic lipoproteins as treatment targets

被引:4
作者
Catapano, Alberico L. [1 ,2 ]
机构
[1] Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy
[2] IRCCS MultiMed, Via Milanese 100, I-20099 Milan, Italy
关键词
CHOLESTEROL; RISK;
D O I
10.1038/nrcardio.2017.221
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Research on dyslipidaemias in 2017 reaffirmed the central role of reducing the levels of atherogenic apolipoprotein B-containing lipoproteins, predominantly LDL, in preventing ischaemic cardiovascular events. However, whether increasing HDL-cholesterol levels in isolation can reduce cardiovascular risk remains to be determined.
引用
收藏
页码:221 / +
页数:2
相关论文
共 10 条
[1]  
[Anonymous], 2017, CELL METAB, DOI [DOI 10.1016/j.cmet.2017.07.012, DOI 10.1136/BMJ.J1648]
[2]   Peptide-Based Anti-PCSK9 Vaccines - An Approach for Long-Term LDLc Management [J].
Galabova, Gergana ;
Brunner, Sylvia ;
Winsauer, Gabriele ;
Juno, Claudia ;
Wanko, Bettina ;
Mairhofer, Andreas ;
Luehrs, Petra ;
Schneeberger, Achim ;
von Bonin, Arne ;
Mattner, Frank ;
Schmidt, Walter ;
Staffler, Guenther .
PLOS ONE, 2014, 9 (12)
[3]   Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial [J].
Giugliano, Robert P. ;
Pedersen, Terje R. ;
Park, Jeong-Gun ;
De Ferrari, Gaetano M. ;
Gaciong, Zbigniew A. ;
Ceska, Richard ;
Toth, Kalman ;
Gouni-Berthold, Ioanna ;
Lopez-Miranda, Jose ;
Schiele, Francois ;
Mach, Francois ;
Ott, Brian R. ;
Kanevsky, Estelle ;
Pineda, Armando Lira ;
Somaratne, Ransi ;
Wasserman, Scott M. ;
Keech, Anthony C. ;
Sever, Peter S. ;
Sabatine, Marc S. .
LANCET, 2017, 390 (10106) :1962-1971
[4]   Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease [J].
Bowman L. ;
Hopewell J.C. ;
Chen F. ;
Wallendszus K. ;
Stevens W. ;
Collins R. ;
Wiviott S.D. ;
Cannon C.P. ;
Braunwald E. ;
Sammons E. ;
Landray M.J. ;
Jiang L. ;
Armitage J. ;
Haynes R. ;
Maggioni A.P. ;
Angermann C.E. ;
Ertl G. ;
Wanner C. ;
Pedersen T. ;
Goto S. ;
Teramoto T. ;
Baigent C. ;
Barter P. ;
Chen Y. ;
Chen Z. ;
Gray A. ;
Mihaylova B. ;
Sleight P. ;
Tobert J. ;
Blaustein R. ;
DeLucca P. ;
Mitchel Y. ;
van Leijenhorst G. ;
Sandercock P. ;
DeMets D. ;
Kjekshus J. ;
Neuberger J. ;
Tonkin A. ;
Emberson J. ;
Granger C. ;
Colhoun H. ;
Barton J. ;
Bray C. ;
Dayanandan R. ;
Knott C. ;
Lay M. ;
Murphy K. ;
Wincott E. ;
Achiri P. ;
Barry S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (13) :1217-1227
[5]   The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice [J].
Landlinger, Christine ;
Pouwer, Marianne G. ;
Juno, Claudia ;
van der Hoorn, Jose W. A. ;
Pieterman, Elsbet J. ;
Jukema, J. Wouter ;
Staffler, Guenther ;
Princen, Hans M. G. ;
Galabova, Gergana .
EUROPEAN HEART JOURNAL, 2017, 38 (32) :2499-U143
[6]   Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol [J].
Ray, Kausik K. ;
Landmesser, Ulf ;
Leiter, Lawrence A. ;
Kallend, David ;
Dufour, Robert ;
Karakas, Mahir ;
Hall, Tim ;
Troquay, Roland P. T. ;
Turner, Traci ;
Visseren, Frank L. J. ;
Wijngaard, Peter ;
Wright, R. Scott ;
Kastelein, John J. P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (15) :1430-1440
[7]  
Sabatine MS, 2017, NEW ENGL J MED, V376, P1713, DOI [10.1056/NEJMoa1615664, 10.4997/JRCPE.2017.212]
[8]   PREVENTION OF CORONARY HEART-DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA [J].
SHEPHERD, J ;
COBBE, SM ;
FORD, I ;
ISLES, CG ;
LORIMER, AR ;
MACFARLANE, PW ;
MCKILLOP, JH ;
PACKARD, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (20) :1301-1307
[9]   Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up [J].
Vallejo-Vaz, Antonio J. ;
Robertson, Michele ;
Catapano, Alberico L. ;
Watts, Gerald F. ;
Kastelein, John J. ;
Packard, Chris J. ;
Ford, Ian ;
Ray, Kausik K. .
CIRCULATION, 2017, 136 (20) :1878-+
[10]   Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis [J].
Wang, Shaohua ;
Cai, Rongrong ;
Yuan, Yang ;
Varghese, Zac ;
Moorhead, John ;
Ruan, Xiong Z. .
SCIENTIFIC REPORTS, 2017, 7