Ruthenium-Catalyzed C-H/N-O Bond Functionalization: Green Isoquinolone Syntheses in Water

被引：318

作者：

Ackermann, Lutz ^{[1
]}

Fenner, Sabine ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

关键词：

DIRECT ARYLATIONS; ROOM-TEMPERATURE; H ACTIVATION; HETEROCYCLES; DERIVATIVES; PALLADIUM; ALKYNES; ARENES; OXIDES;

D O I：

10.1021/ol202861k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium-catalyzed isoquinolone syntheses with ample scope were accomplished through carboxylate assistance in environmentally benign water as a reaction medium. The high chemoselectivity of the ruthenium(II) carboxylate complex also set the stage for the direct use of free hydroxamic acids for annulations of alkynes.

引用

页码：6548 / 6551

页数：4

共 54 条

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Ackermann, L .

ORGANIC LETTERS, 2005, 7 (14) :3123-3125

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Ackermann, Lutz ;

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Ackermann, Lutz ;

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Ackermann, Lutz ;

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ORGANIC LETTERS, 2011, 13 (12) :3278-3281

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Ackermann, Lutz ;

Hofmann, Nora ;

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ORGANIC LETTERS, 2011, 13 (07) :1875-1877

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Ackermann, Lutz ;

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ORGANIC LETTERS, 2010, 12 (21) :5032-5035

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Ackermann, Lutz ;

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CHEMICAL COMMUNICATIONS, 2010, 46 (27) :4866-4877

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (52) :9792-9826

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