Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis

被引:1
|
作者
Gunes, Sezgin [1 ]
Yalaz, Mehmet [1 ]
Sozmen, Eser [2 ]
Altun Koroglu, Ozge [1 ]
Kultursay, Nilgun [1 ]
机构
[1] Ege Univ, Div Neonatol, Dept Pediat, Fac Med, TR-35100 Izmir, Turkey
[2] Ege Univ, Fac Med, Dept Biochem, TR-35100 Izmir, Turkey
关键词
chitotriosidase; morbidity; mortality; newborn; prematurity; NECROTIZING ENTEROCOLITIS; INFLAMMATORY MARKER; CHITINASE FAMILY; GENE-EXPRESSION; SNAPPE-II; ATHEROSCLEROSIS; DISEASE; HEMORRHAGE; CHILDREN; INFANTS;
D O I
10.1111/ped.12532
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundThe aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants. MethodsCord blood chitotriosidase activity was studied in healthy control infants (53 term, group 1; 26 late preterm [33-37gestational weeks], group 2) and 35 preterm infants (32weeks; group 3). In group 3, consecutive samples at 3h, 24h, 72h, 7days, 14days, and 36weeks after conception were also analyzed. Group 3 was also evaluated for mortality, respiratory treatment and bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). ResultsCord blood chitotriosidase activity was positively correlated with gestational age and birthweight. SNAPPE-II score was correlated with chitotriosidase activity at 24h. Consecutive chitotriosidase activity for group 3 was non-significantly higher in infants who died in the early neonatal period. Higher chitotriosidase activity was observed in mechanically ventilated infants than infants treated with non-invasive assisted ventilation. BPD, PDA, IVH and ROP, but not NEC, were related to higher chitotriosidase activity, being significant at some of the time points. ConclusionNeonatal stress such as invasive ventilation may create a risk for the development of BPD, PDA, IVH, and ROP by increasing macrophage activation in preterm infants as reflected in the higher chitotriosidase activity. High chitotriosidase activity may also be associated with disease severity and mortality.
引用
收藏
页码:414 / 421
页数:8
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