Local brain atrophy accounts for functional activity differences in normal aging

被引:74
作者
Kalpouzos, Gregoria [1 ,2 ,3 ]
Persson, Jonas [4 ]
Nyberg, Lars [2 ,3 ,5 ]
机构
[1] Stockholm Univ, Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden
[2] Umea Univ, Dept Integrat Med Biol Physiol, Umea, Sweden
[3] Umea Ctr Funct Brain Imaging, Umea, Sweden
[4] Stockholm Univ, Dept Psychol, S-11330 Stockholm, Sweden
[5] Umea Univ, Dept Radiat Sci Diagnost Radiol, Umea, Sweden
基金
瑞典研究理事会;
关键词
Activation; Atrophy; Compensation; Episodic memory; Frontal lobe; Functional magnetic resonance imaging; Normal aging; Multimodal neuroimaging; Occipital lobe; Parietal lobe; Preservation; Structural magnetic resonance imaging; Voxel-based morphometry; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; EPISODIC MEMORY; PARIETAL CORTEX; WORKING-MEMORY; MATTER VOLUME; OLDER ADULTS; AGE; RETRIEVAL; FMRI;
D O I
10.1016/j.neurobiolaging.2011.02.021
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Functional brain imaging studies of normal aging typically show age-related under-and overactivations during episodic memory tasks. Older individuals also undergo nonuniform gray matter volume (GMv) loss. Thus, age differences in functional brain activity could at least in part result from local atrophy. We conducted a series of voxel-based blood oxygen level-dependent (BOLD)-GMv analyses to highlight whether age-related under-and overrecruitment was accounted for by GMv changes. Occipital GMv loss accounted for underrecruitment at encoding. Efficiency reduction of sensory-perceptual mechanisms underpinned by these areas may partly be due to local atrophy. At retrieval, local GMv loss accounted for age-related overactivation of left dorsolateral prefrontal cortex, but not of left dorsomedial prefrontal cortex. Local atrophy also accounted for age-related overactivation in left lateral parietal cortex. Activity in these frontoparietal regions correlated with performance in the older group. Atrophy in the overrecruited regions was modest in comparison with other regions as shown by a between-group voxel-based morphometry comparison. Collectively, these findings link age-related structural differences to age-related functional under-as well as overrecruitment. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:623.e1 / 623.e13
页数:13
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