Antifungal mechanism of hinokitiol against Candida albicans

被引：51

作者：

Komaki, Nami ^{[1
]}

Watanabe, Toshihiko ^{[1
]}

Ogasawara, Ayako ^{[1
]}

Sato, Norifumi ^{[2
]}

Mikami, Takeshi ^{[1
]}

Matsumoto, Tatsuji ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Dept Microbiol, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] EN Otsuka Pharmaceut Co Ltd, R&D Labs, Hanamaki, Iwate 0250312, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 04期

关键词：

Candida albicans; hinokitiol; ATP; adenylate cyclase (CYR1); RAS1;

D O I：

10.1248/bpb.31.735

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.

引用

页码：735 / 737

页数：3

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