Objective To measure the effect of febuxostat on the serum levels of uric acid (sUA) and the proinflammatory cytokines interleukin (IL)-6, IL-17 and tumour necrosis factor-alpha (TNF-alpha) in Chinese Han patients with gout and hyperuricaemia. Methods This randomized, double-blind, placebo-controlled pilot study enrolled patients with gout and hyperuricaemia (sUA >= 8 mg/dl). Patients were randomized to receive either febuxostat 80 mg or placebo once daily for 24 weeks. The serum levels of sUA, IL-6, IL-17 and TNF-alpha were measured at weeks 0 (baseline), 2, 4, 8, 12, 16 and 24. Baseline clinical and demographic characteristics were recorded for all patients. Results A total of 156 patients were randomized: placebo group (n = 78) and febuxostat group (n = 78). The febuxostat group showed a significantly greater reduction in sUA compared with the placebo group. Serum uric acid concentration was reduced below 8 mg/dl in 46 of 61 patients (75.4%) by week 24. There were also reductions in the serum levels IL-6, IL-17 and TNF-alpha in the febuxostat group. In the febuxostat group, 10 of 78 patients (12.82%) discontinued treatment due to adverse drug reactions. Conclusion Febuxostat reduced the levels of sUA, TNF-alpha, IL-6 and IL-17, but there were some side-effects.
机构:
Sylia Stat, F-92340 Bourg La Reine, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lancrenon, Sylvie
Lanz, Sabine
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h-index: 0
机构:
Labs Mayoly Spindler, F-78400 Chatou, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lanz, Sabine
Delva, Catherine
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h-index: 0
机构:
Sylia Stat, F-92340 Bourg La Reine, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Delva, Catherine
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Guggenbuhl, Pascal
Lambert, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Labs Ipsen Pharma, F-92100 Boulogne, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lambert, Charles
Aubert, Jean-Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, EA Rech Clin Coordonnee Ville Hop Methodol & Soc, F-75018 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Aubert, Jean-Pierre
Saraux, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bretagne Occidentale, CHU Cavale Blanche, Serv Rhumatol, F-29200 Brest, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Saraux, Alain
Ea, Hang-Korng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, F-75205 Paris, France
Hop Lariboisiere, AP HP, Ctr Viggo Petersen, Pole Appareil Locomoteur,Serv Rhumatol, 2 Rue Ambroise Pare, F-75010 Paris, France
Hop Lariboisiere, INSERM, UMR 1132, F-75010 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Ea, Hang-Korng
Liote, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, F-75205 Paris, France
Hop Lariboisiere, AP HP, Ctr Viggo Petersen, Pole Appareil Locomoteur,Serv Rhumatol, 2 Rue Ambroise Pare, F-75010 Paris, France
Hop Lariboisiere, INSERM, UMR 1132, F-75010 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Raucci, Federica
Iqbal, Asif J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci ICVS, Birmingham B15 2TT, W Midlands, EnglandUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Iqbal, Asif J.
Saviano, Anella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Saviano, Anella
Minosi, Paola
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Viale Regina Elena 299, I-00161 Rome, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Minosi, Paola
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Piccolo, Marialuisa
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Irace, Carlo
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Caso, Francesco
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Scarpa, Raffaele
Pieretti, Stefano
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Viale Regina Elena 299, I-00161 Rome, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Pieretti, Stefano
Mascolo, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Mascolo, Nicola
Maione, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
机构:
Univ Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
Royal Brisbane & Womens Hosp, Dept Rheumatol, Brisbane, Qld, AustraliaUniv Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
Robinson, Philip C.
Dalbeth, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Bone & Joint Res Grp, Auckland, New Zealand
Auckland Dist Hlth Board, Dept Rheumatol, Auckland, New ZealandUniv Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
机构:
Natl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
Natl Univ Hlth Syst, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Teng, G. G.
Leung, Y. Y.
论文数: 0引用数: 0
h-index: 0
机构:
Singapore Gen Hosp, Dept Rheumatol & Immunol, Singapore, Singapore
Duke NUS Med Sch Singapore, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Leung, Y. Y.
Ang, L. -W.
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h-index: 0
机构:
Minist Hlth, Epidemiol & Dis Control Div, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Ang, L. -W.
Yuan, J. -M.
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h-index: 0
机构:
Univ Pittsburgh, Inst Canc, Div Canc Control & Populat Sci, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USANatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Yuan, J. -M.
Koh, W. -P.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Univ Hlth Syst, Singapore, Singapore
Duke NUS Med Sch Singapore, Singapore, Singapore
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
机构:
Sylia Stat, F-92340 Bourg La Reine, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lancrenon, Sylvie
Lanz, Sabine
论文数: 0引用数: 0
h-index: 0
机构:
Labs Mayoly Spindler, F-78400 Chatou, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lanz, Sabine
Delva, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Sylia Stat, F-92340 Bourg La Reine, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Delva, Catherine
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Guggenbuhl, Pascal
Lambert, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Labs Ipsen Pharma, F-92100 Boulogne, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Lambert, Charles
Aubert, Jean-Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, EA Rech Clin Coordonnee Ville Hop Methodol & Soc, F-75018 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Aubert, Jean-Pierre
Saraux, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bretagne Occidentale, CHU Cavale Blanche, Serv Rhumatol, F-29200 Brest, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Saraux, Alain
Ea, Hang-Korng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, F-75205 Paris, France
Hop Lariboisiere, AP HP, Ctr Viggo Petersen, Pole Appareil Locomoteur,Serv Rhumatol, 2 Rue Ambroise Pare, F-75010 Paris, France
Hop Lariboisiere, INSERM, UMR 1132, F-75010 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
Ea, Hang-Korng
Liote, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, Sorbonne Paris Cite, F-75205 Paris, France
Hop Lariboisiere, AP HP, Ctr Viggo Petersen, Pole Appareil Locomoteur,Serv Rhumatol, 2 Rue Ambroise Pare, F-75010 Paris, France
Hop Lariboisiere, INSERM, UMR 1132, F-75010 Paris, FranceUniv Catholique Lille, Hop St Philibert, Serv Rhumatol, F-59160 St Philibert, France
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Raucci, Federica
Iqbal, Asif J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci ICVS, Birmingham B15 2TT, W Midlands, EnglandUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Iqbal, Asif J.
Saviano, Anella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Saviano, Anella
Minosi, Paola
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Viale Regina Elena 299, I-00161 Rome, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Minosi, Paola
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Piccolo, Marialuisa
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Irace, Carlo
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Caso, Francesco
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Scarpa, Raffaele
Pieretti, Stefano
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Viale Regina Elena 299, I-00161 Rome, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Pieretti, Stefano
Mascolo, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
Mascolo, Nicola
Maione, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, ItalyUniv Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy
机构:
Univ Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
Royal Brisbane & Womens Hosp, Dept Rheumatol, Brisbane, Qld, AustraliaUniv Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
Robinson, Philip C.
Dalbeth, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Bone & Joint Res Grp, Auckland, New Zealand
Auckland Dist Hlth Board, Dept Rheumatol, Auckland, New ZealandUniv Queensland, Royal Brisbane Hosp, Fac Med, Brisbane, Qld, Australia
机构:
Natl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
Natl Univ Hlth Syst, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Teng, G. G.
Leung, Y. Y.
论文数: 0引用数: 0
h-index: 0
机构:
Singapore Gen Hosp, Dept Rheumatol & Immunol, Singapore, Singapore
Duke NUS Med Sch Singapore, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Leung, Y. Y.
Ang, L. -W.
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth, Epidemiol & Dis Control Div, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Ang, L. -W.
Yuan, J. -M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Inst Canc, Div Canc Control & Populat Sci, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USANatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore
Yuan, J. -M.
Koh, W. -P.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Univ Hlth Syst, Singapore, Singapore
Duke NUS Med Sch Singapore, Singapore, Singapore
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, SingaporeNatl Univ Hlth Syst, Univ Med Cluster, Div Rheumatol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore