Bronchiolitis obliterans postallogeneic stem cell transplantation: What is new?

被引：2
|
作者：
Lemonnier, F. [1 ,2 ]
Dhedin, N. [2 ]
Catherinot, E. [1 ]
Tcherakian, C. [1 ]
Neveu, H. [1 ]
Suarez, F. [3 ]
Becquemin, M. -H. [4 ]
Devillier, P. [5 ,6 ]
Vernant, J. -P. [2 ]
Couderc, L. -J. [1 ,5 ,6 ]
Rivaud, E. [1 ]
机构：
[1] Hop Foch, Serv Pneumol, F-92150 Suresnes, France
[2] Grp Hosp Pitie Salpetriere, Serv Hematol Clin, F-75651 Paris 13, France
[3] Hop Necker Enfants Malad, Serv Hematol Clin, F-75743 Paris, France
[4] Grp Hosp Pitie Salpetriere, Serv Explorat Fonct, F-75651 Paris 13, France
[5] Univ Versailles St Quentin En Yvelines, Fac Med Paris Ile de France Ouest, F-78280 Guyancourt, France
[6] Fac Paris Ile de France Ouest, UPRES EA 220, F-92150 Suresnes, France
来源：
REVUE DE PNEUMOLOGIE CLINIQUE | 2011年 / 67卷 / 04期
关键词：
Obstructive bronchiolitis; Allogeneic hematopoietic stem cell transplantation; Azythromycin; Imatinib; Lung transplantation; VERSUS-HOST-DISEASE; NONINFECTIOUS PULMONARY COMPLICATIONS; ALLOGENEIC MARROW TRANSPLANTATION; GASTROESOPHAGEAL-REFLUX DISEASE; OBSTRUCTIVE AIRWAYS DISEASE; NECROSIS-FACTOR-ALPHA; AIR-FLOW OBSTRUCTION; BONE-MARROW; LUNG TRANSPLANTATION; PSEUDOMONAS-AERUGINOSA;
D O I：
10.1016/j.pneumo.2011.06.003
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Bronchiolitis obliterans (BO) is a severe complication of hematopoietic stem cell transplantation (HSCT). It is considered as a respiratory manifestation of chronic graft-versus-host disease. It is quite similar to the bronchiolitis obliterans after lung transplantation. Classical therapy associates steroids and immunosuppressive drugs, however theses procedure showed a modest efficacy and have an important morbidity. Recent progresses in the physiopathology of BO post-HSCT allow to use new treatments: mTOR inhibitors, immunotherapy, extra-corporeal photochemotherapy, and bronchial anti-inflammatory effects of azithromycin, statins or anti-leucotriens. This review will focus on the use of these new therapies in BO post-HSCT. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：258 / 266
页数：9
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