Insulin Resistance, Hyperglycemia, and Atherosclerosis

被引：632
作者：
Bornfeldt, Karin E. [2 ]
Tabas, Ira [1 ,3 ,4 ]
机构：
[1] Columbia Univ, Dept Med, New York, NY 10032 USA
[2] Univ Washington, Dept Pathol, Diabet & Obes Ctr Excellence, Seattle, WA 98109 USA
[3] Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA
[4] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA
来源：
CELL METABOLISM | 2011年 / 14卷 / 05期
关键词：
ENDOPLASMIC-RETICULUM STRESS; GLYCATION END-PRODUCTS; SMOOTH-MUSCLE; CARDIOVASCULAR-DISEASE; ACCELERATES ATHEROSCLEROSIS; DIABETIC ATHEROSCLEROSIS; GENE-EXPRESSION; GLUCOSE CONTROL; CLINICAL-TRIAL; RECEPTOR;
D O I：
10.1016/j.cmet.2011.07.015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by the epidemic of type 2 diabetes. Further advances in this area demand a thorough understanding of how two major features of type 2 diabetes, insulin resistance and hyperglycemia, impact atherosclerosis. Insulin resistance is associated with systemic CAD risk factors, but increasing evidence suggests that defective insulin signaling in atherosclerotic lesional cells also plays an important role. The role of hyperglycemia in CAD associated with type 2 diabetes is less clear. Understanding the mechanisms whereby type 2 diabetes exacerbates CAD offers hope for new therapeutic strategies to prevent and treat atherosclerotic vascular disease.
引用
收藏
页码：575 / 585
页数：11
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共 92 条
  • [1] Increase in GLUT1 in Smooth Muscle Alters Vascular Contractility and Increases Inflammation in Response to Vascular Injury
    Adhikari, Neeta
    Basi, David L.
    Carlson, Marjorie
    Mariash, Ami
    Hong, Zhigang
    Lehman, Ute
    Mullegama, Sureni
    Weir, Edward K.
    Hall, Jennifer L.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2011, 31 (01) : 86 - +
  • [2] Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3
    Allard, David
    Figg, Nichola
    Bennett, Martin R.
    Littlewood, Trevor D.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (28) : 19739 - 19747
  • [3] Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo
    Azcutia, Veronica
    Abu-Taha, May
    Romacho, Tania
    Vazquez-Bella, Marta
    Matesanz, Nuria
    Luscinskas, Francis W.
    Rodriguez-Manas, Leocadio
    Jesus Sanz, Maria
    Sanchez-Ferrer, Carlos F.
    Peiro, Concepcion
    [J]. PLOS ONE, 2010, 5 (04):
  • [4] The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals Evidence for Interaction With Obesity in Diabetic Patients
    Bacci, Simonetta
    Rizza, Stefano
    Prudente, Sabrina
    Spoto, Belinda
    Powers, Christine
    Facciorusso, Antonio
    Pacilli, Antonio
    Lauro, Davide
    Testa, Alessandra
    Zhang, Yuan-Yuan
    Di Stolfo, Giuseppe
    Mallamaci, Francesca
    Tripepi, Giovanni
    Xu, Rui
    Mangiacotti, Davide
    Aucella, Filippo
    Lauro, Renato
    Gervino, Ernest V.
    Hauser, Thomas H.
    Copetti, Massimiliano
    De Cosmo, Salvatore
    Pellegrini, Fabio
    Zoccali, Carmine
    Federici, Massimo
    Doria, Alessandro
    Trischitta, Vincenzo
    [J]. DIABETES, 2011, 60 (03) : 1000 - 1007
  • [5] Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
    Baumgartl, J
    Baudler, S
    Scherner, M
    Babaev, V
    Makowski, L
    Suttles, J
    McDuffie, M
    Fazio, S
    Kahn, CR
    Hotamisligil, GS
    Krone, W
    Linton, M
    Brüning, JC
    [J]. CELL METABOLISM, 2006, 3 (04) : 247 - 256
  • [6] The obesity epidemic and its cardiovascular consequences
    Behn, Agnieszka
    Ur, Ehud
    [J]. CURRENT OPINION IN CARDIOLOGY, 2006, 21 (04) : 353 - 360
  • [7] Integration of metabolism and inflammation by lipid-activated nuclear receptors
    Bensinger, Steven J.
    Tontonoz, Peter
    [J]. NATURE, 2008, 454 (7203) : 470 - 477
  • [8] Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction
    Boden, G
    Shulman, GI
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 : 14 - 23
  • [9] Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo
    Booth, G
    Stalker, TJ
    Lefer, AM
    Scalia, R
    [J]. DIABETES, 2002, 51 (05) : 1556 - 1564
  • [10] Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    Borradaile, Nica M.
    Han, Xianlin
    Harp, Jeffrey D.
    Gale, Sarah E.
    Ory, Daniel S.
    Schaffer, Jean E.
    [J]. JOURNAL OF LIPID RESEARCH, 2006, 47 (12) : 2726 - 2737
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