Cooperative nanosystems

被引：22

作者：

Guarise, Cristian ^{[1
,2
]}

Manea, Flavio ^{[1
,2
]}

Zaupa, Giovanni ^{[1
,2
]}

Pasquato, Lucia ^{[3
]}

Prins, Leonard J. ^{[1
,2
]}

Scrimin, Paolo ^{[1
,2
]}

机构：

[1] Univ Padua, Dept Chem Sci, I-35131 Padua, Italy

[2] CNR, ITM, Padova Sect, I-35131 Padua, Italy

[3] Univ Trieste, Dept Chem Sci, I-34127 Trieste, Italy

来源：

JOURNAL OF PEPTIDE SCIENCE | 2008年 / 14卷 / 02期

关键词：

peptide; nanoparticle; cooperativity; catalysis; hydrolysis; nanozymes;

D O I：

10.1002/psc.952

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multivalent systems are well known for their enhanced ability to bind multivalent counterparts. This contribution addresses the question whether they can also behave as cooperative catalysts. Analyzing examples from our own laboratory we show that self-assembled systems obtained by covering gold nanoclusters with thiol-terminated amino acids and peptides behave indeed as cooperative catalysts. By comparing their activity profiles with those of discrete, multivalent systems we show what are minimal conditions to elicit cooperativity in multivalent systems. Reactions taken into considerations for our analysis are the hydrolyses of carboxylate- and phosphate esters. Copyright (C) 2008 European Peptide Society and John Wiley & Sons, Ltd.

引用

页码：174 / 183

页数：10

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