2,4,5-Trichlorophenoxyacetic acid inhibits apoptosis in PC12 cells

被引：15
作者：
Yamanoshita, O
Saito, T [1 ]
Takahashi, K
Hosokawa, T
Okabe, M
Ito, K
Kurasaki, M
机构：
[1] Hokkaido Univ, Sch Med, Lab Environm Biol, Dept Preventat Med, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Dept Environm Med & Informat, Sapporo, Hokkaido 0600810, Japan
[3] Hokkaido Univ, Ctr Res & Dev Higher Educ, Res Div Higher Educ, Sapporo, Hokkaido 0600809, Japan
[4] Sci TANAKA Co Ltd, Biotechnol Res Inst, Ishikari, Hokkaido 0613241, Japan
来源：
LIFE SCIENCES | 2001年 / 69卷 / 04期
关键词：
2,4,5-Trichlorophenoxyacetic acid; PC12; cell; apoptosis; endocrine disrupter; differentiation;
D O I：
10.1016/S0024-3205(01)01132-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) is an endocrine disrupter that exerts cytotoxic effects on organisms. In this study, the influence of 2,4,5-T at low concentrations on apoptosis in PC12 cells was investigated. Although no apoptotic features were observed in PC12 cells treated with 2,4,5-T, it inhibited the DNA fragmentation induced by serum deprivation. In addition, the cell viability of PC12 cells increased after treatment with 2,4,5-T. In conclusion, 2,4,5-T suppressed the apoptosis of the cultured cells. Since apoptosis is a morphological and biochemical description of a physiological mechanism of cell death that is commonly associated with programmed events necessary for development of individuals and organs, the inhibitory effect of 2,4,5-T on apoptosis might cause serious damage to cell homeostasis and differentiation. (C) 2001 Elsevier Science Inc. All rights reserved.
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收藏
页码：403 / 408
页数：6
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