The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

被引：149

作者：

Cheng, Shih-Chin ^{[1
,2
]}

van de Veerdonk, Frank L. ^{[1
,2
]}

Lenardon, Megan ^{[3
]}

Stoffels, Monique ^{[1
,2
]}

Plantinga, Theo ^{[1
,2
]}

Smeekens, Sanne ^{[1
,2
]}

Rizzetto, Lisa ^{[4
]}

Mukaremera, Liliane ^{[3
]}

Preechasuth, Kanya ^{[3
]}

Cavalieri, Duccio ^{[4
]}

Kanneganti, Thirumala Devi ^{[5
]}

van der Meer, Jos W. M. ^{[1
,2
]}

Kullberg, Bart Jan ^{[1
,2
]}

Joosten, Leo A. B. ^{[1
,2
]}

Gow, Neil A. R. ^{[3
]}

Netea, Mihai G. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands

[3] Univ Aberdeen, Inst Med Sci, Sch Med Sci, Aberdeen Fungal Grp, Aberdeen AB9 1FX, Scotland

[4] Univ Florence, Dept Preclin & Clin Pharmacol, Florence, Italy

[5] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 90卷 / 02期

基金：

英国惠康基金;

关键词：

Candida; colonization; invasion; IL-1; beta; IL-17; NLRP3; INFLAMMASOME; HOST-DEFENSE; FUNGAL-INFECTIONS; CROHNS-DISEASE; IMMUNE-SYSTEM; CELL-WALL; DECTIN-1; RECOGNITION; MACROPHAGES; ACTIVATION;

D O I：

10.1189/jlb.1210702

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1 beta in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans. J. Leukoc. Biol. 90: 357-366; 2011.

引用

页码：357 / 366

页数：10

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