Warning: the unfortunate end of p-cresol as a uraemic toxin

被引：78
作者：
Vanholder, Raymond [1 ]
Bammens, Bert [2 ]
de Loor, Henriette [2 ]
Glorieux, Griet [1 ]
Meijers, Bjorn [2 ]
Schepers, Eva [1 ]
Massy, Ziad [3 ,4 ,5 ,6 ]
Evenepoel, Pieter [2 ]
机构：
[1] Ghent Univ Hosp, Dept Internal Med, Div Renal, B-9000 Ghent, Belgium
[2] Univ Hosp Leuven, Div Nephrol Dialysis & Transplantat, Louvain, Belgium
[3] INSERM ERI 12, EA 4292, Amiens, France
[4] Amiens Univ Hosp, Div Clin Pharmacol, Amiens, France
[5] Amiens Univ Hosp, Div Nephrol, Amiens, France
[6] Jules Verne Univ Picardie, Amiens, France
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2011年 / 26卷 / 05期
关键词：
MASS SPECTROMETRIC ANALYSIS; CHRONIC KIDNEY-DISEASE; CHRONIC-RENAL-FAILURE; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR RISK; RETENTION SOLUTE; IN-VITRO; REMOVAL; SERUM; CRESYLSULPHATE;
D O I：
10.1093/ndt/gfr056
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
[No abstract available]
引用
收藏
页码：1464 / 1467
页数：4
相关论文
共 38 条
[1]   Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients [J].
Bammens, B ;
Evenepoel, P ;
Keuleers, H ;
Verbeke, K ;
Vanrenterghem, Y .
KIDNEY INTERNATIONAL, 2006, 69 (06) :1081-1087
[2]   Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients [J].
Barreto, Fellype C. ;
Barreto, Daniela V. ;
Liabeuf, Sophie ;
Meert, Natalie ;
Glorieux, Griet ;
Temmar, Mohammed ;
Choukroun, Gabriel ;
Vanholder, Raymond ;
Massy, Ziad A. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (10) :1551-1558
[3]   P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro [J].
Cerini, C ;
Dou, L ;
Anfosso, F ;
Sabatier, F ;
Moal, S ;
Glorieux, G ;
De Smet, R ;
Vanholder, R ;
Dignat-George, F ;
Sampol, J ;
Berland, Y ;
Brunet, P .
THROMBOSIS AND HAEMOSTASIS, 2004, 92 (01) :140-150
[4]   Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum [J].
de Loor, H ;
Bammens, B ;
Evenepoel, P ;
De Preter, V ;
Verbeke, K .
CLINICAL CHEMISTRY, 2005, 51 (08) :1535-1538
[5]   Toxicity of free p-Cresol:: A prospective and cross-sectional analysis [J].
De Smet, R ;
Van Kaer, J ;
Van Vlem, B ;
De Cubber, A ;
Brunet, P ;
Lameire, N ;
Vanholder, R .
CLINICAL CHEMISTRY, 2003, 49 (03) :470-478
[6]   A sensitive HPLC method for the quantification of free and total p-cresol in patients with chronic renal failure [J].
De Smet, R ;
David, F ;
Sandra, P ;
Van Kaer, J ;
Lesaffer, G ;
Dhondt, A ;
Lameire, N ;
Vanholder, R .
CLINICA CHIMICA ACTA, 1998, 278 (01) :1-21
[7]   Uremic toxins originating from colonic microbial metabolism [J].
Evenepoel, Pieter ;
Meijers, Bjorn K. I. ;
Bammens, Bert R. M. ;
Verbeke, Kristin .
KIDNEY INTERNATIONAL, 2009, 76 :S12-S19
[8]   Elevation of circulating endothelial microparticles in patients with chronic renal failure [J].
Faure, V ;
Dou, L ;
Sabatier, F ;
Cerini, C ;
Sampol, J ;
Berland, Y ;
Brunet, P ;
Dignat-George, F .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (03) :566-573
[9]   The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro [J].
Faure, Valerie ;
Cerini, Claire ;
Paul, Pascale ;
Berland, Yvon ;
Dignat-George, Francoise ;
Brunet, Philippe .
INTERNATIONAL IMMUNOLOGY, 2006, 18 (10) :1453-1459
[10]   Protein-Bound Toxins-Update 2009 [J].
Jourde-Chiche, Noemie ;
Dou, Laetitia ;
Cerini, Claire ;
Dignat-George, Francoise ;
Vanholder, Raymond ;
Brunet, Philippe .
SEMINARS IN DIALYSIS, 2009, 22 (04) :334-339
1234