Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

被引：68

作者：

Naz, Safia ^{[1
]}

Shamoon, Muhammad ^{[2
]}

Wang, Rui ^{[1
]}

Zhang, Li ^{[1
]}

Zhou, Juan ^{[1
]}

Chen, Jinghua ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Peoples R China

[2] Australian Natl Univ, Med Sch, Canberra, ACT 2600, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 04期

基金：

中国国家自然科学基金;

关键词：

cancer; drug delivery; inorganic agents; nano-carriers; therapeutics; CALCIUM-PHOSPHATE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; DOUBLE HYDROXIDE NANOPARTICLES; LAYERED DOUBLE HYDROXIDES; WALLED CARBON NANOTUBES; CO-DELIVERY; IN-VITRO; ANTICANCER DRUGS; SIRNA;

D O I：

10.3390/ijms20040965

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

引用

页数：17