Natural killer gene complex (Nkc) allelic variability in inbred mice:: evidence for Nkc haplotypes

被引：45
作者：
Brown, MG
Scalzo, AA
Stone, LR
Clark, PY
Du, Y
Palanca, B
Yokoyama, WM
机构：
[1] Univ Virginia, Sch Med, Dept Internal Med, Div Rheumatol & Immunol, Charlottesville, VA 22908 USA
[2] Washington Univ, Sch Med, Howard Hughes Med Inst, Div Rheumatol, St Louis, MO 63110 USA
[3] Univ Western Australia, Nedlands, WA 6907, Australia
来源：
IMMUNOGENETICS | 2001年 / 53卷 / 07期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
Nkc; allele; haplotype; NK cell; inbred mice;
D O I：
10.1007/s002510100365
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Allelic variability for mouse Chromosome 6 Nkc loci was assessed in 22 common laboratory strains of mice using selected natural killer gene complex (Nkc)linked sequence tagged site markers. Most Nkc markers distinguished three or more alleles for a particular locus in the assessed mouse strains. Nkc locus alleles were highly conserved among genealogically related inbred strains, whereas far less similarity was observed among unrelated strains. Concurrent strain-to-strain comparisons for all Nkc-linked loci revealed common and uncommon Nkc haplotypes, including some that were likely recombinant. Nkc allele and haplotype assignments in inbred mouse strains and correlation with phenotypic traits should facilitate positional gene cloning strategies for unknown Nkc-linked trait modification loci.
引用
收藏
页码：584 / 591
页数：8
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