Thioredoxin interacting protein (TXNIP) rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population

被引：19

作者：

Alvim, R. O. ^{[1
]}

Santos, P. C. J. L. ^{[1
]}

Ferreira, N. E. ^{[1
]}

Mill, J. G.

Krieger, J. E. ^{[1
]}

Pereira, A. C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, Sao Paulo, Brazil

来源：

JOURNAL OF HUMAN HYPERTENSION | 2012年 / 26卷 / 05期

关键词：

GLUCOSE;

D O I：

10.1038/jhh.2011.102

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Thioredoxin interacting protein plays a pivotal role in several important processes of cardiovascular homeostasis by functioning as a biological sensor for biomechanical and oxidative stress. However, the effects of genetic variants in the modulation of arterial stiffness are unknown. In this scenario, the present study evaluated the relationship between the TXNIP rs7212 polymorphism and arterial stiffness. In the overall sample and in the diabetic group, individuals carrying CG + GG genotypes had higher PWV values compared with CC genotype group ( 10.0 vs 9.8 ms(-1), P = 0.03; 12.3 vs 11.2 ms(-1), P = 0.01; respectively). Our findings indicated that the G allele may contribute to increased arterial stiffness in the Brazilian general population and suggest a possible interaction with diabetes.

引用

页码：340 / 342

页数：3

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