A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities

被引：21

作者：

Hu, Xiaokang ^{[1
]}

Wang, Huan ^{[1
]}

Huang, Bo ^{[1
]}

Li, Ni ^{[1
]}

Hu, Kanghong ^{[1
]}

Wu, Baolin ^{[1
]}

Xiao, Zicheng ^{[1
]}

Wei, Yanhong ^{[1
]}

Wu, Pingfan ^{[1
]}

机构：

[1] Hubei Univ Technol, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut, Hubei Prov Key Lab Green Mat Light Ind, Inst POM Based Mat,Sino German Biomed Ctr, Wuhan 430068, Hubei, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2019年 / 193卷

基金：

中国国家自然科学基金;

关键词：

Polyoxovanadates; Amino acids; Organic functionalization; Crystal structure; Antitumor activity; AMINO-ACIDS; POLYOXOMETALATE CLUSTERS; POLYOXOMOLYBDATE; SERIES;

D O I：

10.1016/j.jinorgbio.2019.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents.

引用

页码：130 / 132

页数：3

共 50 条

[41] Rational design of hydrothermal in situ ligand synthesis to fabricate two new coordination polymer
Dai, Yu-Mei
Tang, En
Lin, Ji-Hui
INORGANIC AND NANO-METAL CHEMISTRY, 2023, 53 (01) : 1 - 7
[42] Synthesis, crystal structure, antibacterial and antitumor activities of a new binuclear copper (II) complex containing fluoroquinolone
Wang, GP
Zhu, LG
Yu, QS
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2003, 19 (02) : 179 - 182
[43] Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity
Kwon, Yongseok
Song, Jayoung
Lee, Boeun
In, Jinkyung
Song, Hohyun
Chung, Hwa-Jin
Lee, Sang Kook
Kim, Sanghee
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (04) : 1006 - 1017
[44] Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities
Al-Soud, Y. A.
Al-Masoudi, I. A.
Saeed, B.
Beifuss, U.
Al-Masoudi, N. A.
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (05): : 669 - 676
[45] Design, synthesis, and cytotoxic activities of new 2,4,5-triarylimidazoles
Zarghi, A.
Arfaei, S.
Shirazi, F. H.
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (08) : 3897 - 3904
[46] Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities
Al-Soud Y.A.
Al-Masoudi I.A.
Saeed B.
Beifuß U.
Al-Masoudi N.A.
Chemistry of Heterocyclic Compounds, 2006, 42 (5) : 583 - 590
[47] Design, synthesis, and biological activities of novel thiophene, pyrimidine, pyrazole, pyridine, coumarin and isoxazole: Dydrogesterone derivatives as antitumor agents
El-Sharkawy, Karam A.
Al Bratty, Mohammed
Alhazmi, Hassan A.
Najmi, Asim
OPEN CHEMISTRY, 2021, 19 (01): : 322 - 337
[48] Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA
Liang, Gui-Bin
Wei, Jian-Hua
Jiang, Hong
Huang, Ri-Zhen
Qin, Jing-Ting
Wang, Hui-Ling
Wang, Heng-Shan
Zhang, Ye
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 210
[49] Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities
Ming, Wei
Lu, Wen-Long
Pannecouque, Christophe
Chen, Jiong
Wang, Hai-Feng
Xiao, Ya-Qi
Hu, Sha
Gu, Shuang-Xi
Zhu, Yuan-Yuan
Chen, Fen-Er
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 248
[50] Synthesis, crystal structure, antibacterial and antitumor activities of a new binuclear copper(II) complex with 1,10-phen and fluoroquinolone
Wang, GP
Fu, XC
Zhu, LG
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2003, 19 (09) : 1001 - 1005

← 1 2 3 4 5 →