A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities

被引：21

作者：

Hu, Xiaokang ^{[1
]}

Wang, Huan ^{[1
]}

Huang, Bo ^{[1
]}

Li, Ni ^{[1
]}

Hu, Kanghong ^{[1
]}

Wu, Baolin ^{[1
]}

Xiao, Zicheng ^{[1
]}

Wei, Yanhong ^{[1
]}

Wu, Pingfan ^{[1
]}

机构：

[1] Hubei Univ Technol, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut, Hubei Prov Key Lab Green Mat Light Ind, Inst POM Based Mat,Sino German Biomed Ctr, Wuhan 430068, Hubei, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2019年 / 193卷

基金：

中国国家自然科学基金;

关键词：

Polyoxovanadates; Amino acids; Organic functionalization; Crystal structure; Antitumor activity; AMINO-ACIDS; POLYOXOMETALATE CLUSTERS; POLYOXOMOLYBDATE; SERIES;

D O I：

10.1016/j.jinorgbio.2019.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents.

引用

页码：130 / 132

页数：3

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