Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

被引：546

作者：

Landau, Susan M. ^{[1
]}

Harvey, Danielle ^{[2
]}

Madison, Cindee M. ^{[1
]}

Koeppe, Robert A. ^{[3
]}

Reiman, Eric M. ^{[4
]}

Foster, Norman L. ^{[5
]}

Weiner, Michael W. ^{[6
]}

Jagust, William J. ^{[1
,7
]}

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[2] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

[3] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA

[4] Banner Alzheimers Inst, Phoenix, AZ 85006 USA

[5] Univ Utah, Dept Neurol, Salt Lake City, UT 84108 USA

[6] San Francisco Vet Adm Hosp, San Francisco, CA 94121 USA

[7] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 07期

关键词：

FDG-PET; Alzheimer's disease; Mild cognitive impairment; RANDOM-EFFECTS MODELS; ALZHEIMERS-DISEASE; GLUCOSE-METABOLISM; IMPAIRMENT; PROGRESSION; DEMENTIA; TOMOGRAPHY; PREDICTION; DIAGNOSIS; TRIALS;

D O I：

10.1016/j.neurobiolaging.2009.07.002

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1207 / 1218

页数：12

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