Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external β-turns

被引：26

作者：

Duggan, HME ^{[1
]}

Hitchcock, PB ^{[1
]}

Young, DW ^{[1
]}

机构：

[1] Univ Sussex, Dept Chem, Brighton BN1 9QJ, E Sussex, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 12期

关键词：

D O I：

10.1039/b503014e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride 17 has been carried out and compared to that of the saturated external beta-turn constraint 18.

引用

页码：2287 / 2295

页数：9

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