Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom

被引：61

作者：

Arkhipov, Anton V. ^{[1
,2
]}

Arkhipov, Viatcheslav V. ^{[1
,2
]}

Cossy, Janine ^{[3
]}

Kovtunenko, Volodymir O. ^{[2
]}

Mykhailiuk, Pavel K. ^{[1
,2
,3
]}

机构：

[1] Enamine Ltd, Chervonotkatska 78, UA-02094 Kiev, Ukraine

[2] Natl Taras Shevchenko Univ Kyiv, Dept Chem, Volodymyrska 64, UA-01033 Kiev, Ukraine

[3] PSL Res Univ, UMR 8231, Inst Chem Biol & Innovat CBI, Lab Chim Organ,ESPCI ParisTech,CNRS, 10 Rue Vauquelin, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 14期

关键词：

IN-SITU GENERATION; ELECTRON-DEFICIENT ALKYNES; ION CATALYZED HOMOLOGATION; AMINO-ACID ESTERS; MEDICINAL CHEMISTRY; PERFLUOROALKYLATION REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; FLUORINATED PYRAZOLES; 3-COMPONENT SYNTHESIS; ALKYLBORON COMPOUNDS;

D O I：

10.1021/acs.orglett.6b01565

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

After more than 70 years since its discovery, CF3CHN2 was found to possess a novel reactivity mode: N-terminal electrophile. With C-nucleophiles it gives hydrazones that are easily transformed into valuable CF3-heterocycles.

引用

页码：3406 / 3409

页数：4

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