Metal-free direct regioselective thiolation of imidazoheterocycles in water at room temperature

被引：14

作者：

Kong, Dulin ^{[1
,2
]}

Wang, Qinghe ^{[1
,3
]}

Huang, Tiao ^{[1
,3
]}

Liang, Min ^{[1
,3
]}

Lin, Qiang ^{[1
,3
]}

Wu, Mingshu ^{[1
,3
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Water Pollut Treatment & Resource Reuse H, Haikou 571158, Hainan, Peoples R China

[2] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571199, Hainan, Peoples R China

[3] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Hainan, Peoples R China

来源：

TETRAHEDRON | 2019年 / 75卷 / 10期

关键词：

Metal-free; Thiolation; Imidazoheterocycles; Water; C-H; ONE-POT; SULFENYLATION; THIOLS; ENAMINONES; ACCESS;

D O I：

10.1016/j.tet.2019.01.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free direct thiolation of imidazoheterocycles with various thiophenol in water at room temperature has been developed. In addition, the chemistry provides several advantages including mild condition, high yields, good functional group tolerance, green solvents and suitable for large-scale operations. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1457 / 1463

页数：7

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