The antimycobacterial constituents of dill (Anethum graveolens)

被引：67

作者：

Stavri, M ^{[1
]}

Gibbons, S ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 11期

关键词：

Anethum graveolens; mycobacteria; furanocoumarins; polyacetylenes; antimycobacterial activity;

D O I：

10.1002/ptr.1758

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of a project to characterize selected members of the Kuwaiti flora for their phytochemistry and antimycobacterial activity, a new furanocoumarin, 5-[4"-hydroxy-3"-methyl-r-butenyloxy]-6,7-furocoumarin (3), was isolated from the whole herb of Anethum graveolens. The known compounds oxypeucedanin (1), oxypeucedanin hydrate (2) and falcarindiol (4) were also isolated from this plant. The structure of each compound was determined by interpretation of NMR and mass spectrometric data. The three known compounds exhibited antibacterial activity against a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values in the range 2-128 mu g/mL. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：938 / 941

页数：4

共 21 条

[11] The anti-staphylococcal activity of Angelica dahurica (Bai Zhi) [J].

Lechner, D ;

Stavri, M ;

Oluwatuyi, M ;

Pereda-Miranda, R ;

Gibbons, S .

PHYTOCHEMISTRY, 2004, 65 (03) :331-335

[12] CONSTITUENTS OF UMBELLIFEROUS PLANTS .19. COUMARINS AND TERPENOIDS OF FRUITS OF LIGUSTICUM-SEGUIERI [J].

LEMMICH, J ;

PEDERSEN, PA ;

NIELSEN, BE .

PHYTOCHEMISTRY, 1971, 10 (12) :3333-&

[13] DNA gyrase as a drug target [J].

Maxwell, A .

TRENDS IN MICROBIOLOGY, 1997, 5 (03) :102-109

[14]

Newton SM, 2000, PHYTOTHER RES, V14, P303, DOI 10.1002/1099-1573(200008)14:5&lt

[15]

303::AID-PTR712&gt

[16]

3.0.CO

[17]

2-N

[18] Coumarin inhibitors of gyrase B with N-propargyloxy-carbamate as an effective pyrrole bioisostere [J].

Periers, AM ;

Laurin, P ;

Ferroud, D ;

Haesslein, JL ;

Klich, M ;

Dupuis-Hamelin, C ;

Mauvais, P ;

Lassaigne, P ;

Bonnefoy, A ;

Musicki, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (02) :161-165

[19] Bioactive constituents of Artemisia monosperma [J].

Stavri, M ;

Ford, CHJ ;

Bucar, F ;

Streit, B ;

Hall, ML ;

Williamson, RT ;

Mathew, KT ;

Gibbons, S .

PHYTOCHEMISTRY, 2005, 66 (02) :233-239

[20]

*WHO, 2000, WHO TUB FACT SHEET

← 1 2 3 →