A high sensitive voltammetric sensor for qualitative and quantitative determination of phenobarbital as an antiepileptic drug in presence of acetaminophen

被引:62
作者
Raoof, Jahan Bakhsh [1 ]
Baghayeri, Mehdi [1 ]
Ojani, Reza [1 ]
机构
[1] Univ Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, Iran
关键词
Acetaminophen; Phenobarbital; Pt-nanoparticles; Sensors; Voltammetry; CARBON-PASTE ELECTRODE; PLATINUM NANOPARTICLES; ELECTROCHEMICAL OXIDATION; LIQUID-CHROMATOGRAPHY; P-AMINOPHENOL; NANOTUBES; PHARMACEUTICALS; NOREPINEPHRINE; PARACETAMOL; NANOFIBERS;
D O I
10.1016/j.colsurfb.2012.02.038
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
For the first time, the catalytic activity of phenobarbital (PB) in presence of acetaminophen (AC) was studied at the surface of modified electrode which prepared by incorporation of multi-walled carbon nanotube (MWCNT) and Pt-nanoparticles into a paste matrix. Preparation of this electrode was very simple and modified electrode showed an excellent character for electrocatalytic oxidization of acetaminophen and phenobarbital. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of AC and PB has been explored at the modified electrode. Differential pulse voltammetry peak currents of AC and PB increased linearly with their concentrations at the ranges of 0.5-100 mu M and 0.4-60 mu M, respectively. Also, the detection limits for AC and PB were 0.17 mu M and 0.1 mu M, respectively. The method has been found selective and successfully implemented for the determination of AC and PB in human urine and pharmaceutical samples using standard addition method. The electrode exhibited an efficient catalytic response with good reproducibility and stability. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:121 / 128
页数:8
相关论文
共 51 条
[1]  
[Anonymous], 2001, ELECTROCHEMICAL METH
[2]   Management of epilepsy in adolescents and adults [J].
Brodie, MJ ;
French, JA .
LANCET, 2000, 356 (9226) :323-329
[3]   Methanol oxidation on Pt/Ru, Pt/Ni, and Pt/Ru/Ni anode electrocatalysts at different temperatures for DMFCs [J].
Choi, JH ;
Park, KW ;
Kwon, BK ;
Sung, YE .
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2003, 150 (07) :A973-A978
[4]   An optical fibre reflectance sensor for p-aminophenol determination based on tetrahydroxycalix[4]arene as sensing reagent [J].
Filik, Hayati ;
Aksu, Duygu ;
Apak, Resat ;
Sener, Izzet ;
Kilic, Emine .
SENSORS AND ACTUATORS B-CHEMICAL, 2009, 136 (01) :105-112
[5]   AMPEROMETRIC GLUCOSE SENSORS BASED ON FERROCENE-MODIFIED POLY(ETHYLENE OXIDE) AND GLUCOSE-OXIDASE [J].
HALE, PD ;
LAN, HL ;
BOGUSLAVSKY, LI ;
KARAN, HI ;
OKAMOTO, Y ;
SKOTHEIM, TA .
ANALYTICA CHIMICA ACTA, 1991, 251 (1-2) :121-128
[6]   Determination of ephedrine, theophylline and phenobarbital in a tablet dosage form by capillary electrophoresis [J].
Haque, A ;
Xu, XH ;
Stewart, JT .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 21 (05) :1063-1067
[7]   Electro-oxidation and determination of trazodone at multi-walled carbon nanotube-modified glassy carbon electrode [J].
Hegde, Rajesh N. ;
Shetti, Nagaraj P. ;
Nandibewoor, Sharanappa T. .
TALANTA, 2009, 79 (02) :361-368
[8]   Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes [J].
Hrapovic, S ;
Liu, YL ;
Male, KB ;
Luong, JHT .
ANALYTICAL CHEMISTRY, 2004, 76 (04) :1083-1088
[9]   HELICAL MICROTUBULES OF GRAPHITIC CARBON [J].
IIJIMA, S .
NATURE, 1991, 354 (6348) :56-58
[10]   Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode [J].
Jain, Rajeev ;
Rather, Jahangir Ahmad .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 83 (02) :340-346