A high sensitive voltammetric sensor for qualitative and quantitative determination of phenobarbital as an antiepileptic drug in presence of acetaminophen
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作者:
Raoof, Jahan Bakhsh
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Univ Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, IranUniv Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, Iran
Raoof, Jahan Bakhsh
[1
]
Baghayeri, Mehdi
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Univ Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, IranUniv Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, Iran
Baghayeri, Mehdi
[1
]
Ojani, Reza
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Univ Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, IranUniv Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, Iran
Ojani, Reza
[1
]
机构:
[1] Univ Mazandaran, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar, Iran
For the first time, the catalytic activity of phenobarbital (PB) in presence of acetaminophen (AC) was studied at the surface of modified electrode which prepared by incorporation of multi-walled carbon nanotube (MWCNT) and Pt-nanoparticles into a paste matrix. Preparation of this electrode was very simple and modified electrode showed an excellent character for electrocatalytic oxidization of acetaminophen and phenobarbital. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of AC and PB has been explored at the modified electrode. Differential pulse voltammetry peak currents of AC and PB increased linearly with their concentrations at the ranges of 0.5-100 mu M and 0.4-60 mu M, respectively. Also, the detection limits for AC and PB were 0.17 mu M and 0.1 mu M, respectively. The method has been found selective and successfully implemented for the determination of AC and PB in human urine and pharmaceutical samples using standard addition method. The electrode exhibited an efficient catalytic response with good reproducibility and stability. (C) 2012 Elsevier B.V. All rights reserved.
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Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, ScotlandUniv Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland
Brodie, MJ
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French, JA
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机构:Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland
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Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Hrapovic, S
;
Liu, YL
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Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Liu, YL
;
Male, KB
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Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Male, KB
;
Luong, JHT
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Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
机构:
Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, ScotlandUniv Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland
Brodie, MJ
;
French, JA
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机构:Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland
机构:
Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Hrapovic, S
;
Liu, YL
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机构:
Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Liu, YL
;
Male, KB
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h-index: 0
机构:
Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
Male, KB
;
Luong, JHT
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机构:
Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada