Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study
被引:145
作者:
Fu, Benjamin C.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Fu, Benjamin C.
[1
,2
,3
]
Hullar, Meredith A. J.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Hullar, Meredith A. J.
[1
]
Randolph, Timothy W.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Randolph, Timothy W.
[1
]
Franke, Adrian A.
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机构:
Univ Hawaii Manoa, Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Franke, Adrian A.
[4
]
Monroe, Kristine R.
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机构:
Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Monroe, Kristine R.
[5
]
Cheng, Iona
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机构:
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Cheng, Iona
[6
]
Wilkens, Lynne R.
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机构:
Univ Hawaii Manoa, Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Wilkens, Lynne R.
[4
]
Shepherd, John A.
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Univ Hawaii Manoa, Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Shepherd, John A.
[4
]
Madeleine, Margaret M.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Madeleine, Margaret M.
[1
]
Le Marchand, Loic
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机构:
Univ Hawaii Manoa, Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Le Marchand, Loic
[4
]
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Lim, Unhee
[4
]
Lampe, Johanna W.
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机构:
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Lampe, Johanna W.
[1
,2
]
机构:
[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[3] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[4] Univ Hawaii Manoa, Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA
[5] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA
[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA
Background: Trimethylamine N-oxide (TMAO), a compound derived from diet and metabolism by the gut microbiome, has been associated with several chronic diseases, although the mechanisms of action are not well understood and few human studies have investigated microbes involved in its production. Objectives: Our study aims were 1) to investigate associations of TMAO and its precursors (choline, carnitine, and betaine) with inflammatory and cardiometabolic risk biomarkers; and 2) to identify fecal microbiome profiles associated with TMAO. Methods: We conducted a cross-sectional analysis using data collected from 1653 participants (826 men and 827 women, aged 60-77 y) in the Multiethnic Cohort Study. Plasma concentrations of TMAO and its precursors were measured by LC-tandem MS. We also analyzed fasting blood for markers of inflammation, glucose and insulin, cholesterol, and triglycerides (TGs), and further measured blood pressure. Fecal microbiome composition was evaluated by sequencing the 16S ribosomal RNA gene V1V3 region. Associations of TMAO and its precursors with disease risk biomarkers were assessed by multivariable linear regression, whereas associations between TMAO and the fecal microbiome were assessed by permutational multivariate ANOVA and hurdle regression models using the negative binomial distribution. Results: Median (IQR) concentration of plasma TMAO was 3.05 mu mol/L (2.10-4.60 mu mol/L). Higher concentrations of TMAO and carnitine, and lower concentrations of betaine, were associated with greater insulin resistance (all P < 0.02). Choline was associated with higher systolic blood pressure, TGs, lipopolysaccharide-binding protein, and lower HDL cholesterol (P ranging from <0.001 to 0.03), reflecting an adverse cardiometabolic risk profile. TMAO was associated with abundance of 13 genera (false discovery rate< 0.05), including Prevotella, Mitsuokella, Fusobacterium, Desulfovibrio, and bacteria belonging to the families Ruminococcaceae and Lachnospiraceae, as well as the methanogen Methanobrevibacter Conclusions: Plasma TMAO concentrations were associated with a number of trimethylamine-producing bacterial taxa, and, along with its precursors, may contribute to inflammatory and cardiometabolic risk pathways.
机构:
Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Bae, Sajin
;
Ulrich, Cornelia M.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
German Canc Res Ctr, Heidelberg, Germany
Natl Ctr Tumor Dis, Heidelberg, Germany
Huntsman Canc Inst, Salt Lake City, UT USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Ulrich, Cornelia M.
;
Neuhouser, Marian L.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Neuhouser, Marian L.
;
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Malysheva, Olga
;
Bailey, Lynn B.
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h-index: 0
机构:
Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Bailey, Lynn B.
;
Xiao, Liren
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Xiao, Liren
;
Brown, Elissa C.
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机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Brown, Elissa C.
;
Cushing-Haugen, Kara L.
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Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Cushing-Haugen, Kara L.
;
Zheng, Yingye
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Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Zheng, Yingye
;
Cheng, Ting-Yuan David
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Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Cheng, Ting-Yuan David
;
Miller, Joshua W.
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机构:
Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA
Univ Calif Davis, Dept Med Pathol & Lab Med, Davis, CA 95616 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Miller, Joshua W.
;
Green, Ralph
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Univ Calif Davis, Dept Med Pathol & Lab Med, Davis, CA 95616 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Green, Ralph
;
Lane, Dorothy S.
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机构:
SUNY Stony Brook, Sch Med, Dept Prevent Med, Stony Brook, NY 11794 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Lane, Dorothy S.
;
Beresford, Shirley A. A.
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Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Beresford, Shirley A. A.
;
Caudill, Marie A.
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Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Caporaso, J. Gregory
;
Kuczynski, Justin
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Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Kuczynski, Justin
;
Stombaugh, Jesse
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Stombaugh, Jesse
;
Bittinger, Kyle
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Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Bittinger, Kyle
;
Bushman, Frederic D.
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Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Bushman, Frederic D.
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Costello, Elizabeth K.
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Costello, Elizabeth K.
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Fierer, Noah
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Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA
Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Fierer, Noah
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Pena, Antonio Gonzalez
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Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Pena, Antonio Gonzalez
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Goodrich, Julia K.
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Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Goodrich, Julia K.
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Gordon, Jeffrey I.
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Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Gordon, Jeffrey I.
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Huttley, Gavin A.
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Australian Natl Univ, John Curtin Sch Med Res, Computat Genom Lab, Canberra, ACT 2601, AustraliaUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Huttley, Gavin A.
;
Kelley, Scott T.
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San Diego State Univ, Dept Biol, San Diego, CA 92182 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Kelley, Scott T.
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Knights, Dan
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Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Knights, Dan
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Koenig, Jeremy E.
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Cornell Univ, Dept Microbiol, Ithaca, NY USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Koenig, Jeremy E.
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Ley, Ruth E.
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Cornell Univ, Dept Microbiol, Ithaca, NY USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Ley, Ruth E.
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Lozupone, Catherine A.
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Lozupone, Catherine A.
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McDonald, Daniel
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
McDonald, Daniel
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Muegge, Brian D.
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Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Muegge, Brian D.
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Pirrung, Meg
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Pirrung, Meg
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Reeder, Jens
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Reeder, Jens
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Sevinsky, Joel R.
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Luca Technol, Golden, CO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Sevinsky, Joel R.
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Tumbaugh, Peter J.
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Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Tumbaugh, Peter J.
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Walters, William A.
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Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Walters, William A.
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Widmann, Jeremy
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Widmann, Jeremy
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Yatsunenko, Tanya
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Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Yatsunenko, Tanya
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Zaneveld, Jesse
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Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Zaneveld, Jesse
;
Knight, Rob
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Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Chen, Ming-liang
;
Yi, Long
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Yi, Long
;
Zhang, Yong
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhang, Yong
;
Zhou, Xi
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhou, Xi
;
Ran, Li
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Ran, Li
;
Yang, Jining
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Yang, Jining
;
Zhu, Jun-dong
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhu, Jun-dong
;
Zhang, Qian-yong
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhang, Qian-yong
;
Mi, Man-tian
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Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
机构:
Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Bae, Sajin
;
Ulrich, Cornelia M.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
German Canc Res Ctr, Heidelberg, Germany
Natl Ctr Tumor Dis, Heidelberg, Germany
Huntsman Canc Inst, Salt Lake City, UT USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Ulrich, Cornelia M.
;
Neuhouser, Marian L.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Neuhouser, Marian L.
;
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Malysheva, Olga
;
Bailey, Lynn B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Bailey, Lynn B.
;
Xiao, Liren
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Xiao, Liren
;
Brown, Elissa C.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Brown, Elissa C.
;
Cushing-Haugen, Kara L.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Cushing-Haugen, Kara L.
;
Zheng, Yingye
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Zheng, Yingye
;
Cheng, Ting-Yuan David
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Cheng, Ting-Yuan David
;
Miller, Joshua W.
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA
Univ Calif Davis, Dept Med Pathol & Lab Med, Davis, CA 95616 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Miller, Joshua W.
;
Green, Ralph
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Dept Med Pathol & Lab Med, Davis, CA 95616 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Green, Ralph
;
Lane, Dorothy S.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Stony Brook, Sch Med, Dept Prevent Med, Stony Brook, NY 11794 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Lane, Dorothy S.
;
Beresford, Shirley A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Beresford, Shirley A. A.
;
Caudill, Marie A.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USACornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Caporaso, J. Gregory
;
Kuczynski, Justin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Kuczynski, Justin
;
Stombaugh, Jesse
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h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Stombaugh, Jesse
;
Bittinger, Kyle
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h-index: 0
机构:
Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Bittinger, Kyle
;
Bushman, Frederic D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Bushman, Frederic D.
;
Costello, Elizabeth K.
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h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Costello, Elizabeth K.
;
Fierer, Noah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA
Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Fierer, Noah
;
Pena, Antonio Gonzalez
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h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Pena, Antonio Gonzalez
;
Goodrich, Julia K.
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h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Goodrich, Julia K.
;
Gordon, Jeffrey I.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Gordon, Jeffrey I.
;
Huttley, Gavin A.
论文数: 0引用数: 0
h-index: 0
机构:
Australian Natl Univ, John Curtin Sch Med Res, Computat Genom Lab, Canberra, ACT 2601, AustraliaUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Huttley, Gavin A.
;
Kelley, Scott T.
论文数: 0引用数: 0
h-index: 0
机构:
San Diego State Univ, Dept Biol, San Diego, CA 92182 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Kelley, Scott T.
;
Knights, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Knights, Dan
;
Koenig, Jeremy E.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Microbiol, Ithaca, NY USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Koenig, Jeremy E.
;
Ley, Ruth E.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Microbiol, Ithaca, NY USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Ley, Ruth E.
;
Lozupone, Catherine A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Lozupone, Catherine A.
;
McDonald, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
McDonald, Daniel
;
Muegge, Brian D.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Muegge, Brian D.
;
Pirrung, Meg
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Pirrung, Meg
;
Reeder, Jens
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Reeder, Jens
;
Sevinsky, Joel R.
论文数: 0引用数: 0
h-index: 0
机构:
Luca Technol, Golden, CO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Sevinsky, Joel R.
;
Tumbaugh, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Tumbaugh, Peter J.
;
Walters, William A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Walters, William A.
;
Widmann, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Widmann, Jeremy
;
Yatsunenko, Tanya
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Yatsunenko, Tanya
;
Zaneveld, Jesse
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Zaneveld, Jesse
;
Knight, Rob
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USAUniv Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Chen, Ming-liang
;
Yi, Long
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Yi, Long
;
Zhang, Yong
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhang, Yong
;
Zhou, Xi
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhou, Xi
;
Ran, Li
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Ran, Li
;
Yang, Jining
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Yang, Jining
;
Zhu, Jun-dong
论文数: 0引用数: 0
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机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhu, Jun-dong
;
Zhang, Qian-yong
论文数: 0引用数: 0
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机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China
Zhang, Qian-yong
;
Mi, Man-tian
论文数: 0引用数: 0
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机构:
Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R ChinaThird Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing, Peoples R China