Broken asymmetry of the human heartbeat: Loss of time irreversibility in aging and disease

被引:201
作者
Costa, M [1 ]
Goldberger, AL
Peng, CK
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02215 USA
[2] Univ Lisbon, Fac Sci, Inst Biophys & Biomed Engn, P-1749016 Lisbon, Portugal
关键词
D O I
10.1103/PhysRevLett.95.198102
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Time irreversibility, a fundamental property of nonequilibrium systems, should be of importance in assessing the status of physiological processes that operate over a wide range of scales. However, measurement of this property in living systems has been limited. We provide a computational method derived from basic physics assumptions to quantify time asymmetry over multiple scales and apply it to the human heartbeat time series in health and disease. We find that the multiscale time asymmetry index is highest for a time series from young subjects and decreases with aging or heart disease. Loss of time irreversibility may provide a new way of assessing the functionality of living systems that operate far from equilibrium.
引用
收藏
页数:4
相关论文
共 20 条
  • [1] BRAUN C, 1998, AM J PHYSIOL, V275, pH1557
  • [2] ASYMMETRIC UNBIASED FLUCTUATIONS ARE SUFFICIENT FOR THE OPERATION OF A CORRELATION RATCHET
    CHIALVO, DR
    MILLONAS, MM
    [J]. PHYSICS LETTERS A, 1995, 209 (1-2) : 26 - 30
  • [3] Multiscale entropy analysis of biological signals
    Costa, M
    Goldberger, AL
    Peng, CK
    [J]. PHYSICAL REVIEW E, 2005, 71 (02):
  • [4] Multiscale entropy analysis of complex physiologic time series
    Costa, M
    Goldberger, AL
    Peng, CK
    [J]. PHYSICAL REVIEW LETTERS, 2002, 89 (06) : 1 - 068102
  • [5] COX DR, 1981, SCAND J STAT, V8, P93
  • [6] Travelling waves in the occurrence of dengue haemorrhagic fever in Thailand
    Cummings, DAT
    Irizarry, RA
    Huang, NE
    Endy, TP
    Nisalak, A
    Ungchusak, K
    Burke, DS
    [J]. NATURE, 2004, 427 (6972) : 344 - 347
  • [7] Symbolic approach for measuring temporal "irreversibility"
    Daw, CS
    Finney, CEA
    Kennel, MB
    [J]. PHYSICAL REVIEW E, 2000, 62 (02): : 1912 - 1921
  • [8] REVERSIBILITY AS A CRITERION FOR DISCRIMINATING TIME-SERIES
    DIKS, C
    VANHOUWELINGEN, JC
    TAKENS, F
    DEGOEDE, J
    [J]. PHYSICS LETTERS A, 1995, 201 (2-3) : 221 - 228
  • [9] Using time domain characteristics to discriminate physiologic and Parkinsonian tremors
    Edwards, R
    Beuter, A
    [J]. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2000, 17 (01) : 87 - 100
  • [10] The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis
    Huang, NE
    Shen, Z
    Long, SR
    Wu, MLC
    Shih, HH
    Zheng, QN
    Yen, NC
    Tung, CC
    Liu, HH
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1998, 454 (1971): : 903 - 995