Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

被引：22

作者：

Bigot, Jeanne ^{[1
]}

Guillot, Loic ^{[2
]}

Guitard, Juliette ^{[1
]}

Ruffin, Manon ^{[2
]}

Corvol, Harriet ^{[3
]}

Balloy, Viviane ^{[2
]}

Hennequin, Christophe ^{[1
]}

机构：

[1] Sorbonne Univ, Ctr Rech St Antoine, Serv Parasitol Mycol, Hop St Antoine,AP HP,INSERM,CRSA, Paris, France

[2] Sorbonne Univ, Ctr Rech St Antoine, INSERM, Paris, France

[3] Sorbonne Univ, Ctr Rech St Antoine, Serv Pneumol Pediat, Hop Trousseau,AP HP,INSERM,CRSA, Paris, France

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

bronchial epithelial cells; Aspergillus fumigatus; innate immunity; lung infection; mucociliary machinery; LONG PENTRAXIN PTX3; TOLL-LIKE RECEPTORS; ANTIMICROBIAL PEPTIDES; CYSTIC-FIBROSIS; ANTIFUNGAL ACTIVITY; TRAINED IMMUNITY; CONIDIA; DEFENSE; RECOGNITION; ACTIVATION;

D O I：

10.3389/fimmu.2020.01041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the air, and the first encounter of this fungus in the human host is most likely with the bronchial epithelial cells. Although alveolar macrophages have been widely studied in the Aspergillus-lung interaction, increasing evidence suggests that bronchial epithelium plays a key role in responding to the fungus. This review focuses on the innate immune response of the bronchial epithelial cells against A. fumigatus, the predominant pathogenic species. We have also detailed the molecular interactants and the effects of the different modes of interaction between these cells and the fungus.

引用

页数：11

共 104 条

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