Comparative timing measurements of LYSO and LFS-3 to achieve the best time resolution for TOF-PET

The best Coincidence Time Resolution (CTR) obtained so far - with very short crystals of 3-5 mm in length - reach values between 100 and 150 ps. Such crystals are not really practical for a TOF PET imaging device, since the sensitivity is quite small for the detection of the 511 keV gammas resulting from a positron annihilation. We present our setup and measurements using 15 mm length crystals; a length we regard as reasonable for a TOF-PET scanner. We have used a new series of Silicon PhotoMultipliers (SiPM) manufactured by Hamamatsu. These are the High Fill Factor (HFF) and Low Cross-Talk (LCT) Multi-Pixel Photon Counters (MPPC). We have compared three different crystals, LFS-3 (supplied by Zecotek) and two samples of LYSO (manufactured by Saint Gobain and CPI). We have obtained an excellent value of 148 ps for the Coincidence Time Resolution (CTR) with two LFS-3 crystals (15 mm long) mounted on each side of a Na-22 radioactive source with the HFF-MPPCs at 3.3 V over-voltage. Our results are148 ps obtained with LFS-3 and 170 ps with LYSO crystals using identical SiPMs and electronics. (C) 2015 Elsevier B.V. All rights reserved.