Doxorubicin loaded PEG-b-poly(4-vinylbenzylphosphonate) coated magnetic iron oxide nanoparticles for targeted drug delivery

被引：28

作者：

Halupka-Bryl, Magdalena ^{[1
,2
,3
]}

Bednarowicz, Magdalena ^{[1
,2
,3
]}

Dobosz, Bernadeta ^{[1
,2
]}

Krzyminiewski, Ryszard ^{[1
,2
]}

Zalewski, Tomasz ^{[1
]}

Wereszczynska, Beata ^{[4
]}

Nowaczyk, Grzegorz ^{[1
]}

Jarek, Marcin ^{[1
]}

Nagasaki, Yukio ^{[3
,5
,6
,7
]}

机构：

[1] Adam Mickiewicz Univ, NanoBioMed Ctr, PL-61620 Poznan, Poland

[2] Adam Mickiewicz Univ, Fac Phys, Div Med Phys, PL-61620 Poznan, Poland

[3] Univ Tsukuba, Grad Sch Pure & Appl Sci, Dept Mat Sci, Tsukuba, Ibaraki 305, Japan

[4] Adam Mickiewicz Univ, Dept Macromol Phys, PL-61620 Poznan, Poland

[5] Univ Tsukuba, Grad Sch Comprehens Human Sci, Masters Sch Med Sci, Tsukuba, Ibaraki 305, Japan

[6] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton Satellite WPI MANA, Tsukuba, Ibaraki 3050047, Japan

[7] Univ Tsukuba, Tsukuba, Ibaraki 305, Japan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2015年 / 384卷

关键词：

Iron oxide nanoparticles; Superparamagnetism; Electron spin resonance; Magnetic resonance; Drug delivery; ELECTRON-PARAMAGNETIC-RESONANCE; IN-VITRO; CENTERS; SYSTEM;

D O I：

10.1016/j.jmmm.2015.02.078

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Due to their unique physical properties, superparamagnetic iron oxide nanoparticles are increasingly used in medical applications. They are very useful carriers for delivering antitumor drugs in targeted cancer treatment. Magnetic nanoparticles with chemiotherapeutic were synthesized by coprecipitation method followed by coaling with biocompatible polymer. The aim of this work is to characterize physical and magnetic properties of synthesized nanoparicles. Characterization was carried out using EPR, HRTEM, X-ray diffraction, SQUID and NMR methods. The present findings show that synthesized nanosystem is promising tool for potential magnetic drug delivery. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：320 / 327

页数：8

共 40 条

[1] Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis [J].