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Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma
被引:41
作者:
Zhang, Guqin
[2
]
Nie, Hanxiang
[1
]
Yang, Jiong
[2
]
Ding, Xuhong
[1
]
Huang, Yi
[1
]
Yu, Hongying
[1
]
Li, Ruyou
[1
]
Yuan, Zhuqing
[1
]
Hu, Suping
[1
]
机构:
[1] Wuhan Univ, Renmin Hosp, Dept Resp Med, Wuhan 430060, Hubei, Peoples R China
[2] Wuhan Univ, Zhongnan Hosp, Dept Resp Med, Wuhan 430060, Hubei, Peoples R China
基金:
中国国家自然科学基金;
关键词:
natural killer T cell;
KILLER T-CELLS;
HYPERREACTIVITY;
SUBSETS;
INNATE;
SUFFICIENT;
IMMUNITY;
DISTINCT;
D O I:
10.1152/ajplung.00114.2011
中图分类号:
Q4 [生理学];
学科分类号:
071003 ;
摘要:
Zhang G, Nie H, Yang J, Ding X, Huang Y, Yu H, Li R, Yuan Z, Hu S. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol 301: L975-L984, 2011. First published August 19, 2011; doi: 10.1152/ajplung.00114.2011.-Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play a crucial role in the development of asthma. However, the roles of type II NKT cells in asthma have not been investigated before. Interestingly, type I and type II NKT cells have been shown to have opposing roles in antitumor immunity, antiparasite immunity, and autoimmunity. We hypothesized that sulfatide-activated type II NKT cells could prevent allergic airway inflammation by inhibiting type I NKT cell function in asthma. Strikingly, in our mouse model, activation of type II NKT cells by sulfatide administration and adoptive transfer of sulfatide-activated type II NKT cells result in reduced-inflammation cell infiltration in the lung and bronchoalveolar lavage fluid, decreased levels of IL-4 and IL-5 in the BALF; and decreased serum levels of ovalbumin-specific IgE and IgG1. Furthermore, it is found that the activation of sulfatide-reactive type II NKT cells leads to the functional inactivation of type I NKT cells, including the proliferation and cytokine secretion. Our data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation.
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页码:L975 / L984
页数:10
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