共 23 条
Impact of histopathological transformation and overall survival in patients with progressive anaplastic glioma
被引:7
作者:

Ho, Allen L.
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Stanford Univ, Dept Neurosurg, Palo Alto, CA 94304 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Koch, Matthew J.
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机构:
Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Tanaka, Shota
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机构:
Tokyo Univ Hosp, Tokyo, Japan Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Eichler, April F.
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机构:
Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Batchelor, Tracy T.
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Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Tanboon, Jantima
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Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Louis, David N.
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Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Cahill, Daniel P.
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Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Chi, Andrew S.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA

Curry, William T., Jr.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
机构:
[1] Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02115 USA
[5] Stanford Univ, Dept Neurosurg, Palo Alto, CA 94304 USA
[6] Tokyo Univ Hosp, Tokyo, Japan
[7] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
关键词:
Anaplastic glioma;
Glioblastoma;
Malignant glioma;
Recurrent glioma;
Transformation;
MALIGNANT GLIOMA;
PHASE-II;
RADIOTHERAPY;
OLIGODENDROGLIOMAS;
CLASSIFICATION;
CRITERIA;
TUMORS;
D O I:
10.1016/j.jocn.2016.02.019
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Progression of anaplastic glioma (World Health Organization [WHO] grade III) is typically determined radiographically, and transformation to glioblastoma (GB) (WHO grade IV) is often presumed at that time. However, the frequency of actual histopathologic transformation of anaplastic glioma and the subsequent clinical impact is unclear. To determine these associations, we retrospectively reviewed all anaplastic glioma patients who underwent surgery at our center at first radiographic progression, and we examined the effects of histological diagnosis, clinical history, and molecular factors on transformation rate and survival. We identified 85 anaplastic glioma (39 astrocytoma, 24 oligodendroglioma, 22 oligoastrocytoma), of which 38.8% transformed to GB. Transformation was associated with shorter overall survival (OS) from the time of diagnosis (3.4 vs. 10.9 years, p = 0.0005) and second surgery (1.0 vs. 3.5 years, p < 0.0001). Original histologic subtype did not significantly impact the risk of transformation or OS. No other factors, including surgery, adjuvant therapy or molecular markers, significantly affected the risk of transformation. However, mutations in isocitrate dehydrogenase 1 (IDH1) was associated with longer time to progression (median 4.6 vs. 1.4 years, p = 0.008) and OS (median 10.0 vs. 4.2 years, p = 0.046). At radiographic progression, tissue diagnosis may be warranted as histologic grade may provide valuable prognostic information and affect therapeutic clinical trial selection criteria for this patient population. (C) 2016 Elsevier Ltd. All rights reserved.
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页码:99 / 105
页数:7
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