Impact of histopathological transformation and overall survival in patients with progressive anaplastic glioma

被引:7
作者
Ho, Allen L. [5 ]
Koch, Matthew J. [3 ,4 ]
Tanaka, Shota [6 ]
Eichler, April F. [1 ,2 ,4 ]
Batchelor, Tracy T. [1 ,2 ,4 ]
Tanboon, Jantima [7 ]
Louis, David N. [1 ,2 ,4 ,7 ]
Cahill, Daniel P. [1 ,2 ,3 ,4 ]
Chi, Andrew S. [1 ,2 ,4 ]
Curry, William T., Jr. [1 ,2 ,3 ,4 ]
机构
[1] Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, 55 Fruit St Y9E, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Dept Neurol, 55 Fruit St Y9E, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02115 USA
[5] Stanford Univ, Dept Neurosurg, Palo Alto, CA 94304 USA
[6] Tokyo Univ Hosp, Tokyo, Japan
[7] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
关键词
Anaplastic glioma; Glioblastoma; Malignant glioma; Recurrent glioma; Transformation; MALIGNANT GLIOMA; PHASE-II; RADIOTHERAPY; OLIGODENDROGLIOMAS; CLASSIFICATION; CRITERIA; TUMORS;
D O I
10.1016/j.jocn.2016.02.019
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Progression of anaplastic glioma (World Health Organization [WHO] grade III) is typically determined radiographically, and transformation to glioblastoma (GB) (WHO grade IV) is often presumed at that time. However, the frequency of actual histopathologic transformation of anaplastic glioma and the subsequent clinical impact is unclear. To determine these associations, we retrospectively reviewed all anaplastic glioma patients who underwent surgery at our center at first radiographic progression, and we examined the effects of histological diagnosis, clinical history, and molecular factors on transformation rate and survival. We identified 85 anaplastic glioma (39 astrocytoma, 24 oligodendroglioma, 22 oligoastrocytoma), of which 38.8% transformed to GB. Transformation was associated with shorter overall survival (OS) from the time of diagnosis (3.4 vs. 10.9 years, p = 0.0005) and second surgery (1.0 vs. 3.5 years, p < 0.0001). Original histologic subtype did not significantly impact the risk of transformation or OS. No other factors, including surgery, adjuvant therapy or molecular markers, significantly affected the risk of transformation. However, mutations in isocitrate dehydrogenase 1 (IDH1) was associated with longer time to progression (median 4.6 vs. 1.4 years, p = 0.008) and OS (median 10.0 vs. 4.2 years, p = 0.046). At radiographic progression, tissue diagnosis may be warranted as histologic grade may provide valuable prognostic information and affect therapeutic clinical trial selection criteria for this patient population. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:99 / 105
页数:7
相关论文
共 23 条
[1]   Oligodendrogliomas: Molecular Biology and Treatment [J].
Bromberg, Jacolien E. C. ;
van den Bent, Martin J. .
ONCOLOGIST, 2009, 14 (02) :155-163
[2]   Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402 [J].
Cairncross, Gregory ;
Berkey, Brian ;
Shaw, Edward ;
Jenkins, Robert ;
Scheithauer, Bernd ;
Brachman, David ;
Buckner, Jan ;
Fink, Karen ;
Souhami, Luis ;
Laperierre, Normand ;
Mehta, Minesh ;
Curran, Walter .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (18) :2707-2714
[3]   Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors [J].
Calli, Cem ;
Kitis, Omer ;
Yunten, Nigun ;
Yurtseven, Taskin ;
Islekel, Sertac ;
Akalin, Taner .
EUROPEAN JOURNAL OF RADIOLOGY, 2006, 58 (03) :394-403
[4]   Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors [J].
Capper, David ;
Weissert, Susanne ;
Balss, Joerg ;
Habel, Antje ;
Meyer, Jochen ;
Jaeger, Diana ;
Ackermann, Ulrike ;
Tessmer, Claudia ;
Korshunov, Andrey ;
Zentgraf, Hanswalter ;
Hartmann, Christian ;
von Deimling, Andreas .
BRAIN PATHOLOGY, 2010, 20 (01) :245-254
[5]   Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine [J].
Dias-Santagata, Dora ;
Akhavanfard, Sara ;
David, Serena S. ;
Vernovsky, Kathy ;
Kuhlmann, Georgiana ;
Boisvert, Susan L. ;
Stubbs, Hannah ;
McDermott, Ultan ;
Settleman, Jeffrey ;
Kwak, Eunice L. ;
Clark, Jeffrey W. ;
Isakoff, Steven J. ;
Sequist, Lecia V. ;
Engelman, Jeffrey A. ;
Lynch, Thomas J. ;
Haber, Daniel A. ;
Louis, David N. ;
Ellisen, Leif W. ;
Borger, Darrell R. ;
Lafrate, A. John .
EMBO MOLECULAR MEDICINE, 2010, 2 (05) :146-158
[6]   Finding the anaplastic focus in diffuse gliomas: The value of Gd-DTPA enhanced MRI, FET-PET, and intraoperative, ALA-derived tissue fluorescence [J].
Ewelt, Christian ;
Floeth, Frank W. ;
Felsberg, Joerg ;
Steiger, Hans J. ;
Sabel, Michael ;
Langen, Karl-Josef ;
Stoffels, Gabriele ;
Stumrner, Walter .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2011, 113 (07) :541-547
[7]   Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis [J].
Jaeckle, K. A. ;
Decker, P. A. ;
Ballman, K. V. ;
Flynn, P. J. ;
Giannini, C. ;
Scheithauer, B. W. ;
Jenkins, R. B. ;
Buckner, J. C. .
JOURNAL OF NEURO-ONCOLOGY, 2011, 104 (01) :253-259
[8]   Target volumes in radiotherapy for high-grade malignant glioma of the brain [J].
Jansen, EPM ;
Dewit, LGH ;
van Herk, M ;
Bartelink, H .
RADIOTHERAPY AND ONCOLOGY, 2000, 56 (02) :151-156
[9]   The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007) [J].
Louis, David N. ;
Ohgaki, Hiroko ;
Wiestler, Otmar D. ;
Cavenee, Webster K. ;
Burger, Peter C. ;
Jouvet, Anne ;
Scheithauer, Bernd W. ;
Kleihues, Paul .
ACTA NEUROPATHOLOGICA, 2007, 114 (05) :547-547
[10]   RESPONSE CRITERIA FOR PHASE-II STUDIES OF SUPRATENTORIAL MALIGNANT GLIOMA [J].
MACDONALD, DR ;
CASCINO, TL ;
SCHOLD, SC ;
CAIRNCROSS, JG .
JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (07) :1277-1280