Voltammetric study of acetazolamide and its determination in human serum and urine using carbon paste electrode modified by gold nanoparticle

被引：15

作者：

Gholivand, Mohammad Bagher ^{[1
]}

Parvin, Mohammad Hadi ^{[1
]}

机构：

[1] Razi Univ, Fac Chem, Dept Analyt Chem, Kermanshah, Iran

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2011年 / 660卷 / 01期

关键词：

Acetazolamide (ACZ); Carbon paste electrode; Modified electrode; Gold nanoparticle; Voltammetry; ELECTROCHEMICAL CHARACTERIZATION; MICROELECTRODE-ARRAYS; CYCLIC VOLTAMMETRY; BIOLOGICAL-FLUIDS; AU; POLYPYRROLE; SIMULATION; REDUCTION; PALLADIUM; BIOSENSOR;

D O I：

10.1016/j.jelechem.2011.06.026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A carbon paste electrode modified with gold nanoparticle was prepared and used for low level acetazolamide (ACZ) determination in aqueous media. The measurement was made using differential pulse voltammetry. The influence of some experimental variables such as carbon paste composition, working solution pH, supporting electrolyte, scan rate, pulse amplitude and possible interferences were studied. The prepared and characterized modified carbon paste electrode demonstrated a linear current response over the concentration range between 0.01 mu M and 80.0 mu M ACZ, with a detection limit of 7.1 nM. The proposed sensor exhibited a high sensitivity and good selectivity and was applied for clinical evaluation of ACZ. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：163 / 168

页数：6

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