Differences in mitochondrial DNA copy number between patients with bipolar I and II disorders

被引:14
作者
Chung, Jae Kyung [1 ]
Ahn, Yong Min [2 ,3 ,4 ]
Kim, Soon Ae [5 ]
Joo, Eun-Jeong [6 ,7 ]
机构
[1] Eumsung Somang Hosp, Dept Psychiat, Eumsung, South Korea
[2] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea
[3] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
[4] Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, Seoul, South Korea
[5] Eulji Univ, Sch Med, Dept Pharmacol, 77 Gyeryong Ro 771 Beon Gil, Daejeon 34824, South Korea
[6] Eulji Univ, Sch Med, Dept Neuropsychiat, Daejeon, South Korea
[7] Eulji Univ, Nowon Eulji Med Ctr, Dept Psychiat, 68 Hangeulbiseokro, Seoul 01830, South Korea
关键词
Bipolar I disorder; Bipolar II disorder; Mitochondrial DNA copy number; MAGNETIC-RESONANCE-SPECTROSCOPY; GENOME-WIDE ASSOCIATION; PERIPHERAL-BLOOD; OXIDATIVE DAMAGE; BASAL GANGLIA; DYSFUNCTION; ANTIDEPRESSANTS; EXPRESSION; HEALTH; MOOD;
D O I
10.1016/j.jpsychires.2020.11.016
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Mitochondria play a critical role in energy metabolism. Genetic, postmortem brain, and brain imaging studies of bipolar disorder (BD) patients indicated that mitochondrial dysfunction might explain BD pathophysiology. Mitochondrial function can be indirectly evaluated by measuring mitochondrial DNA (mtDNA) copy numbers. We recruited 186 bipolar I disorder (BD1) and 95 bipolar II disorder (BD2) patients, and age- and sex-matched controls. MtDNA copy numbers in peripheral blood cells were measured via quantitative polymerase chain reaction. We explored parameters (including age and clinical features) that might affect mtDNA copy numbers. We found that BD1 patients had a lower mtDNA copy number than controls and that mtDNA copy number was negatively associated with the number of mood episodes. BD2 patients had a higher mtDNA copy number than controls. Thus, changes in mitochondrial function may influence BD pathophysiology. The opposite directions of the association with mtDNA copy number in BD1 and BD2 patients suggests that the difference in pathophysiology may be associated with mitochondrial function.
引用
收藏
页码:325 / 333
页数:9
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