A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos

被引：9

作者：

Chen, Ting ^{[1
,2
,3
,4
]}

Hua, La ^{[1
,2
,3
]}

Chou, Guixin ^{[1
,2
,3
]}

Mao, Xudong ^{[1
,2
,3
]}

Zou, Xianliang ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China

[3] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China

[4] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350122, Fujian, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 10期

关键词：

Poria cocos; lanostane triterpenoids; naphthalenone derivative; cancer cell line; cytotoxic activity; LANOSTANE-TYPE TRITERPENES; SORBICILLIN; INHIBITION; CELLS; ACID;

D O I：

10.3390/molecules23102508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A previously undescribed naphthalenone derivative, sohiracillinone (1), and a novel 4,5-seco-lanostane triterpenoid, 11 beta-ethoxydaedaleanic acid A (2) were isolated with two new lanostane triterpenoids, ceanphytamic acids A (3) and B (4), from the EtOH extract of Poria cocos along with 17 known compounds 5-21. The absolute configuration of sohiracillinone (1) was unambiguously identified by NMR and electronic circular dichroism (ECD) data. The structures of other new compounds were elucidated on the basis of NMR and mass spectroscopy (MS), and the cytotoxic activities of all the isolated components were evaluated.

引用

页数：11

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